Evidence mapPaperPMID 41724658Full record

ArticleJournal of diabetes science and technology2026

Marked Increases in Continuous Glucose Monitor-Detected Hypoglycemia During a Seven-Day Water-Only Fast in Healthy Men and Women.

Kristoffer J Kolnes, Lauren V Turner, Steffen Brufladt, Emelie T F Nilsen, Anders J Kolnes, Stephen O'Rahilly, Jørgen Jensen, Michael C Riddell

Abstract read
In one paragraph

Article in Journal of diabetes science and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kristoffer J KolnesDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.ORCID 0000-0001-8824-5173
Lauren V TurnerSchool of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada.ORCID 0000-0002-3882-4123
Steffen BrufladtDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Emelie T F NilsenDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Anders J KolnesSection of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, Oslo, Norway.
Stephen O'RahillyMRC Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Jørgen JensenDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Michael C RiddellSchool of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada.ORCID 0000-0001-6556-7559

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiday fasting is practiced globally for various health or religious reasons which can cause marked declines in circulating glucose levels. Yet, the extent of hypoglycemia exposure (ie, blood glucose <70 mg/dL), as measured by continuous glucose monitoring (CGM) during a prolonged fast is unclear. We aimed to determine the distribution of interstitial glucose data as measured by CGM, during a seven-day water-only fast in healthy men and women.

methodsThis study used interstitial glucose levels from CGM (Dexcom G4 Platinum) to profile hypoglycemic exposure during a seven-day water-only fast in 12 healthy adults (seven men; age 29.7 ± 6.1 years; body mass index [BMI] 25.0 ± 3.3 kg/m²) that also included physical performance tests (day 6) and an oral glucose tolerance test (day 7).

resultsTime <70 mg/dL increased from 3.0% ± 7.1% at baseline to 66.0% ± 25.7% by day 5 (

conclusionsThis research demonstrated considerable hypoglycemia exposure occurs without symptoms in heathy men and women who undertake multiday fasting.

Indexed as

Blood GlucoseFastingHypoglycemiaAdultContinuous Glucose MonitoringFemaleGlucose Tolerance TestHumansMaleTime FactorsWaterYoung AdultBlood GlucoseWaterCGMexercisefastinghypoglycemiametabolic regulationOGTT

Identifiers

PMID41724658
PMCPMC12929083

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.