Evidence map›Paper›PMID 41724666›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.

Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W M A D Binosha Fernando, Belinda Brown, Samantha L Gardener, Stephanie R Rainey-Smith, Ralph Martins, Prashant Bharadwaj

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ajish AriyathCentre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.
Zoe MputhiaCentre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.
Christopher DoughertyCentre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.
Bushra Kaleelur RahumanCentre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.
W M A D Binosha FernandoCentre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.
Belinda BrownCentre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.
Samantha L GardenerCentre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.
Stephanie R Rainey-SmithCentre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.
Ralph MartinsCentre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.
Prashant BharadwajCentre of Excellence for Alzheimer's disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Nedlands, Western Australia, Australia.ORCID https://orcid.org/0000-0003-4361-9906

Funding

Australian Research Council Dementia Research Development Fellowship (MRC-ARC) APP1107109National Foundation for Medical Research and InnovationNational Health and Medical Research Council
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive, age-related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction. Autophagy, a cellular degradation and recycling process, plays a vital role in maintaining neuronal health and is increasingly recognized as a therapeutic target in AD. Lifestyle factors such as diet, physical activity, and sleep can positively influence autophagy and support cognitive function. Intermittent fasting (IF) and calorie restriction (CR) activate autophagy and promote longevity; physical activity enhances cerebral blood flow and neurotrophic signaling; and adequate sleep supports autophagic processes, while sleep deprivation disrupts them. However, excessive autophagy may be detrimental. Understanding how lifestyle modulates autophagy is essential for developing non-pharmacological strategies to delay or prevent AD. This review explores the mechanistic links between autophagy and lifestyle interventions to support brain health in aging.

Indexed as

Alzheimer DiseaseAutophagyDietExerciseSleepAnimalsBrainCaloric RestrictionHumansIntermittent FastingSignal TransductionAlzheimer's diseaseamyloid beta proteinamyloid precursor proteinautophagycalorie restrictiondietexercisefastinglifestyle interventionsphysical activitysleepsleep deprivationsleep fragmentation

Identifiers

PMID41724666
PMCPMC12928064

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.