Evidence map›Paper›PMID 41724999›Full record

ArticlePsychophysiology2026

Confirmation of a Useful Dark-Room Resting-State Procedure: Periodic and Aperiodic MEG Activity in Children.

Marybeth McNamee, Heather L Green, Guannan Shen, Marissa DiPiero, Drayton L Murray, Mia Pearce, Alice Onyango-Opiyo, Song Liu, Lisa Blaskey, Emily S Kuschner and 5 more

Abstract read
In one paragraph

Article in Psychophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marybeth McNameeLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Heather L GreenLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Guannan ShenLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Marissa DiPieroLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Drayton L MurrayLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Mia PearceLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0009-7013-9466
Alice Onyango-OpiyoLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Song LiuLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Lisa BlaskeyLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Emily S KuschnerLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Mina KimLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Rose E FranzenLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Gregory A MillerDepartment of Psychology, University of California, Los Angeles, California, USA.
Yuhan ChenLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
J Christopher EdgarLurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-6731-5443

Funding

A longitudinal study of brain development in children with autismR01MH107506 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI James Christopher EDGAR · 2016 to 2026
$7.5M
Brain structure and function in infantsR01HD093776 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI James Christopher EDGAR · 2018 to 2026
$5.7M
Neural markers of late language emergence in preschool children born very and extremely pretermR01HD119165 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI CHEN, YU-HAN · 2025 to 2025
$2.4M
Functional connectivity in autism spectrum disordersR21MH098204 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI EDGAR, JAMES CHRISTOPHER · 2013 to 2014
$461k
Thalamic activity and structure and surface neural oscillations in autismR21NS090192 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI EDGAR, JAMES CHRISTOPHER · 2015 to 2016
$390k
Identifying optimal electrophysiological markers for predicting developmental outcomes in infantsK08HD114880 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Heather Lee Green · 2025 to 2026
$294k
National Institute of Child Health and Human Development GRT-00003651National Institute of Child Health and Human Development R01HD093776National Institute of Child Health and Human Development R01HD119165NICHD NIH HHS K08 HD114880NICHD NIH HHS R01 HD093776NICHD NIH HHS R01 HD119165NIMH NIH HHS R01 MH107506NIMH NIH HHS R01MH107506NIMH NIH HHS R21 MH098204NIMH NIH HHS R21MH098204NIMH NIH HHS R21NS090192NINDS NIH HHS R21 NS090192
6 · The paper itself

Abstract

In a previous paper, we showed in children 6-12 years old that a resting-state (RS) eyes-open dark room (DR) task provides RS parietal-occipital alpha measures similar to those obtained using the standard RS eyes-closed (EC) exam. Results provided initial evidence that the RS DR procedure is feasible and useful with populations often excluded from electrophysiology RS studies, such as participants who cannot remain awake with their eyes closed or cannot remain still for an extended period. The present study extended the DR and EC comparisons to a much larger sample of children spanning a wider age range and expanded the analysis strategy to examine RS aperiodic measures (offset and slope [exponent] of the power spectrum) and to evaluate 15 distinct brain regions rather than just the previously examined parieto-occipital RS periodic alpha activity. RS activity was recorded using MEG, here reporting on 147 DR and EC datasets obtained from children (including 23 with evaluable datasets at multiple timepoints) with typical development (TD; N = 69) and children with autism spectrum disorder (ASD; N = 53) 7.7-17.1 years old. Findings showed good reliability in both TD and ASD for the EC and DR parietal-occipital peak alpha frequency (frequency with highest alpha power; interclass correlation [ICC] = 0.84, p < 0.001). The ICC for periodic parieto-occipital PAF power was lower (ICC = 0.65). For offset and exponent, the two RS aperiodic measures, fair to good reliability for both groups was observed between DR and EC at all 15 brain regions (mean and median ICC values 0.77-0.80). Offset and exponent values differed significantly across the 15 brain regions, as did associations between age and both aperiodic measures. Findings confirm that the DR exam is a viable way to obtain RS periodic and aperiodic measures. The lack of TD/ASD differences in the EC and DR periodic and aperiodic ICCs supports the generalizability of the DR procedure. Finally, regional differences in aperiodic measures demonstrate the need to assess aperiodic activity in brain source space rather than scalp sensor space.

Indexed as

Alpha RhythmAutism Spectrum DisorderBrainCerebral CortexMagnetoencephalographyRestAdolescentChildFemaleHumansMalealpha poweraperiodicautism spectrum disordermagnetoencephalographypeak alpha frequencyperiodicresting‐state alphatypically developing

Identifiers

PMID41724999
PMCPMC12926522

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.