ArticleDiabetology & metabolic syndrome2026
The effect of high intensity interval training on body composition, metabolic, inflammatory and oxidative stress markers in adolescents with obesity.
Article in Diabetology & metabolic syndrome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe aim of the study is to evaluate the effects of 12-week high-intensity interval training (HIIT) on body composition, metabolic hormones, insulin resistance, lipid profile, inflammation, and oxidative stress markers in adolescents with obesity.
methodsThirty-two (female = 19; male = 13) adolescent volunteers with obesity were divided into two groups: training and control. Participants underwent health checks with resting electrocardiogram (ECG) and blood pressure monitoring. Anthropometric measurements, body composition components, and biochemical tests were performed in pre and post-tests of all participants. Serum fasting glucose, insulin, total cholesterol, triglyceride, high and low-density lipoproteins, leptin, adiponectin, High-Sensitivity C-Reactive Protein (hs-CRP), Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), hs-CRP, TNF-alpha, IL-6, prooxidant, and antioxidant parameters were analyzed biochemically. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated. The training group participated in a HIIT program for 12 weeks, 3 days a week, for a total of 36 sessions, after 3 weeks of pre-adaptation studies. Heart rate was monitored with a heart rate monitor. The control group was not included in any exercise program during this period.
resultsThe mean age of the adolescents with obesity included in the study was 15.28 ± 2.93 years and Body Mass Index (BMI) was 33.21 ± 4.98 kg/m2. Group, sex, and time interaction effects showed that HOMA-IR and triglyceride levels had reduced in the HIIT group (p < 0.001). The group-time interaction effect was observed in the parameters related to body composition, metabolism, inflammation, and pro-oxidant status (p < 0.05). BMI, waist and hip circumferences, body fat (%), insulin, glucose, total cholesterol, LDL, triglyceride, and leptin were decreased in the HIIT group (p < 0.05). While lean mass, muscle mass, body water and adiponectin were increased in the HIIT intervention group (p < 0.05). The inflammation parameters (hs-CRP, TNF-α, and IL-6), and pro-oxidant indicator Advanced Glycation End Products (AGEs) were decreased in the HIIT group.
conclusionA 12-week HIIT program in adolescents with obesity has positive effects on body composition, metabolic parameters, inflammation, and oxidative stress markers. These benefits may contribute to healthy growth and developmental processes. HIIT represents a time-efficient, practical, and effective strategy to mitigate obesity-related metabolic and inflammatory disturbances while strengthening antioxidant defenses.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.