Evidence map›Paper›PMID 41725121›Full record

ArticleObesity (Silver Spring, Md.)2026

Adipose Tissue-Derived Small Extracellular Vesicles in Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance.

Shalini Mishra, Yixin Su, Ashish Kumar, Sangeeta Singh, Brian S Finlin, Fang-Chi Hsu, Jingyun Lee, Cristina M Furdui, Philip A Kern, Swapan K Das and 1 more

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shalini MishraSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Yixin SuSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Ashish KumarSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Sangeeta SinghSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Brian S FinlinDepartment of Internal Medicine, Division of Endocrinology, University of Kentucky, Lexington, Kentucky, USA.
Fang-Chi HsuDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jingyun LeeAtrium Health Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Cristina M FurduiAtrium Health Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Philip A KernDepartment of Internal Medicine, Division of Endocrinology, University of Kentucky, Lexington, Kentucky, USA.
Swapan K DasSection of Endocrinology and Metabolism, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0002-2197-8855
Gagan DeepSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Exosome Mediated Alterations in Cellular Metabolism in the Pathogenesis and Progression of Alzheimer's DiseaseR01AG061805 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOLINA, ANTHONY J · 2018 to 2022
$3.5M
Consumer-based meditation app, Calm, for treatment of sleep disturbance in hematological cancer patientsR01CA262041 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jennifer Lynne Huberty, Ruben A. Mesa · 2022 to 2026
$2.8M
Effects of Fish Oil on Inflammation and Metabolic SyndromeR01DK080327 · NIDDK · UNIV OF ARKANSAS FOR MED SCIS · PI KERN, PHILIP A · 2008 to 2012
$1.7M
Multi-Ethnic Study of Atherosclerosis- Cellular Exosomes in Neurodegeneration and Dementia (MESA-CEND)R01AG068629 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEEP, GAGAN, HUGHES, TIMOTHY M. · 2024 to 2025
$1.5M
NCATS NIH HHS UL1 TR001998NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA262041NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG061805NIA NIH HHS R01 AG068629NIDDK NIH HHS R01 DK080327Office of Extramural Research, National Institutes of Health AG061805Office of Extramural Research, National Institutes of Health P30CA012197Office of Extramural Research, National Institutes of Health RF1AG068629
6 · The paper itself

Abstract

objectiveGlucose tolerance (GT) is a major effector for adipose tissue (AT) remodeling in obesity, yet its molecular mechanisms remain incompletely defined. We hypothesized that the biophysical and molecular profiles of AT-derived small extracellular vesicles (sEV

methodssEV

resultThe size and concentration of sEV

conclusionsDistinct molecular signatures in sEV

Indexed as

Adipose TissueExtracellular VesiclesGlucose IntoleranceAdultAnimalsAntigens, CDFemaleGlucose Tolerance TestHumansInsulinMaleMiceMicroRNAsMuscle Fibers, SkeletalObesityProteomicsAntigens, CDINSR protein, humanInsulinMicroRNAsMIRN145 microRNA, humanReceptor, Insulin

Identifiers

PMID41725121
PMCPMC13032056

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.