Evidence map›Paper›PMID 41725127›Full record

ArticleAdvanced healthcare materials2026

Detection of Extracellular Vesicles with Colocalized Surface Markers via a Capture-Release-Capture Strategy for Treatment Monitoring in Ewing Sarcoma.

You-Ren Ji, Yong Ju, Hui Kong, Yaya Xu, Chen Zhao, Ryan Zhang, Yue Ma, Lynn L Zheng, Lucy R Shi, Alex Wu and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

You-Ren JiCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Yong JuCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Hui KongDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Yaya XuCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Chen ZhaoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Ryan ZhangCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Yue MaCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Lynn L ZhengCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Lucy R ShiCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Alex WuCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Lu-An LinCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Carina Peijia WuCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Audrey QianCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Emily RenCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Christine ZhangDepartment of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Kenny VoDepartment of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Sarah DryDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Joseph G CromptonDivision of Surgical Oncology, David Geffen School of Medicine, Los Angeles, California, USA.
Noah FedermanDepartment of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
Yazhen ZhuCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Steven J JonasORCID https://orcid.org/0000-0002-8111-0249
Hsian-Rong TsengCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-0942-5905
Shaohua LuDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Junseok LeeCalifornia Nanosystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-3709-1386

Funding

Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular CarcinomaR01CA255727 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 to 2025
$2.5M
Translational development of osteosarcoma (OS) extracellular vesicle (EV) matrix metalloproteinase (MMP) Activity Assay for assessing patient treatment responsesR01CA298883 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$2.1M
Developing and Automating an Extracellular Vesicle-Based Test for Early Detection of Hepatocellular CarcinomaR44CA288163 · EXIMIUS DIAGNOSTICS CORP · 2025 to 2025
$662k
Click Chemistry-Mediated Surface Protein Assay for Quantifying Subpopulations of Hepatocellular Carcinoma-associated Extracellular VesiclesR01CA277530 · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2025 to 2025
$662k
Hyundai Hope on Wheels Foundation for Childhood Cancer Research 1475032Hyundai Hope on Wheels Foundation for Childhood Cancer Research 20233377National Institutes of Health (NIH) DP5OD028181National Institutes of Health (NIH) R01CA246304National Institutes of Health (NIH) R01CA253651National Institutes of Health (NIH) R01CA253651-04S1National Institutes of Health (NIH) R01CA255727National Institutes of Health (NIH) R01CA277530National Institutes of Health (NIH) R01CA298883National Institutes of Health (NIH) R21CA280444National Institutes of Health (NIH) R44CA288163National Institutes of Health (NIH) U01EB026421NCI NIH HHS R01 CA246304NCI NIH HHS R01 CA253651NCI NIH HHS R01 CA255727NCI NIH HHS R01 CA277530NCI NIH HHS R01 CA298883NCI NIH HHS R21 CA280444NCI NIH HHS R44 CA288163NIBIB NIH HHS U01 EB026421NIH HHS DP5 OD028181
6 · The paper itself

Abstract

Ewing Sarcoma (ES) is a rare but aggressive malignancy of bone tissue in adolescents and young adults, where early detection of progression and real-time treatment monitoring remain unmet clinical needs. Tumor extracellular vesicles (EVs) carry surface markers and nucleic acid cargo that can serve as minimally invasive biomarkers, but single-marker EV assays often lack specificity, and colocalized-marker approaches may suffer from low sensitivity. Here, we report the ES EV Capture-Release-Capture (CaReCa) assay, a two-step enrichment strategy that combines desthiobiotin (DTB)-mediated capture/release of CD99

Indexed as

Biomarkers, TumorBone NeoplasmsExtracellular VesiclesSarcoma, EwingAdolescentFemaleHumansMaleBiomarkers, Tumorcancer diagnosiscolocalized surface markersEwing sarcomaextracellular vesiclesliquid biopsy

Identifiers

PMID41725127
PMCPMC13078352

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.