ArticleLipids2026
Higher Increases in Plasma n-3 Polyunsaturated Fatty Acids Following Fish Oil Supplementation in Postmenopausal Females Compared With Age-Matched Males.
Article in Lipids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
The effects of fish oil supplementation on omega-3 (n-3) polyunsaturated fatty acids, particularly intermediates between eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), that may provide valuable metabolic information, have not been fully characterized in older populations. A total of 10 postmenopausal females (69.6 ± 2.6 years, mean ± SEM) and 10 age-matched males (70.0 ± 2.4) were supplemented with fish oil (1.8 g/day EPA and 1.4 g/day DHA) for 5 months, and blood was collected to determine n-3 PUFA levels. Significant interaction effects (sex × supplementation) for plasma phospholipid EPA, DHA, and 24:5n-3 (p < 0.05) revealed 69%, 101%, and 182% higher levels, respectively, in females compared with males post-supplementation. Significant main effects of supplementation yielded 83%-327% higher plasma triacylglycerol EPA, DHA, 22:5n-3, and 24:5n-3 (p < 0.05) post-supplementation. Our findings provide insight into sex-dependent DHA metabolism in healthy older adults, which may help inform more targeted EPA and/or DHA supplementation advice to promote improved n-3 PUFA status.
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