Evidence map›Paper›PMID 41725237›Full record

ArticleJournal of cardiovascular electrophysiology2026

Pulsed Field Versus Radiofrequency Ablation in Concomitant Pulmonary Vein Isolation and LAA Occlusion: Impact on Peridevice Leak and Procedural Efficiency.

Mohammad Montaser Atasi, Shea Hubbard, Charles Campbell, Charbel Noujaim, Christian M Massad, Michel Abou Khalil, Yara Menassa, Alex El Darzi, Maximilian Moersdorf, Carlo El Khoury and 14 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Mohammad Montaser AtasiTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.ORCID 0009-0008-2046-209X
Shea HubbardTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Charles CampbellTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Charbel NoujaimTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Christian M MassadTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.ORCID 0009-0002-3441-0617
Michel Abou KhalilTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Yara MenassaTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Alex El DarziTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Maximilian MoersdorfTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Carlo El KhouryTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Chanho LimTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Yingshuo LiuTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Yishi JiaTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Abboud HassanTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Mayana BsoulTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Ghassan BidaouiTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0002-3562-7386
Hadi YounesTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0002-7202-1164
Monique YoungTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Bassam WannaTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Amitabh C PandeyTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Omar KreidiehTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0001-6189-2821
Han FengTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Qussay MarashlyTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.
Nassir F MarroucheTulane Research Innovation for Arrhythmia Discovery, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0003-0454-0541

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConcomitant pulmonary vein isolation (PVI) and left atrial appendage occlusion (LAAO) is increasingly performed in patients with atrial fibrillation (AF) at elevated thromboembolic risk. Radiofrequency ablation (RFA) has been the conventional approach, but pulsed field ablation (PFA) may reduce tissue edema, procedural duration, and peridevice leak (PDL).

objectiveTo compare safety, efficacy, and PDL rates between PFA + LAAO and RFA + LAAO.

methodsIn this single-center, retrospective study, 175 consecutive patients undergoing LAAO with or without concomitant PVI between September 2021 and May 2025 were included: RFA + LAAO (n = 61), PFA + LAAO (n = 39), and LAAO-only (n = 75). Procedural data, device characteristics, and complications were collected. The primary endpoint was PDL at 45-day follow-up transesophageal echocardiography (TEE). Secondary endpoints included procedure duration, vascular and esophageal complications, device-related thrombosis, and arrhythmia recurrence.

resultsBaseline characteristics were generally balanced, although RFA + LAAO patients were younger. No large PDL (> 5 mm) was observed. At 45 days, small PDL (≤ 5 mm) was significantly higher in RFA + LAAO (23%) vs. PFA + LAAO (5.1%) and LAAO-only (9.3%; p = 0.015). Mean procedure duration was shorter with PFA + LAAO (67.1 ± 10.4 min) compared with RFA + LAAO (99.6 ± 12.8 min; p < 0.001). Major complications and device-related thrombosis were rare. Minor complications and AF recurrence were comparable across groups.

conclusionsConcomitant PFA + LAAO is associated with lower PDL incidence and shorter procedural times compared with RFA + LAAO, without compromising safety.

Indexed as

Atrial FibrillationCatheter AblationLeft Atrial Appendage ClosurePulmonary VeinsAction PotentialsAgedFemaleHeart RateHumansIrreversible Electroporation TherapyMaleMiddle AgedRecurrenceRetrospective StudiesRisk AssessmentRisk Factorsatrial fibrillationleft atrial appendage occlusionperidevice leakpulmonary vein isolationpulsed field ablationradiofrequency ablation

Identifiers

PMID41725237
PMCPMC13069918

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.