Article in Circulation. Cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01174550 (PROspective Multicenter Imaging Study for Evaluation of Chest Pain - The PROMISE Trial), which is not on this map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Jan M BrendelDepartment of Radiology, Cardiovascular Imaging Research Center (CIRC) (J.M.B., J.K., N.M.K., I.L.L., M.J., M.C.L., M.T.L., B.F.), Massachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0002-2729-610X
Thomas MayrhoferCenter for Preventive Medicine and Digital Health, Medical Faculty Mannheim, Heidelberg University, Germany (T.M.).
Júlia KarádyDepartment of Radiology, Cardiovascular Imaging Research Center (CIRC) (J.M.B., J.K., N.M.K., I.L.L., M.J., M.C.L., M.T.L., B.F.), Massachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0002-6640-6260
Márton KolossváryMetabolism Unit (M.K.), Massachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0002-5570-991X
Nóra M KerkovitsDepartment of Radiology, Cardiovascular Imaging Research Center (CIRC) (J.M.B., J.K., N.M.K., I.L.L., M.J., M.C.L., M.T.L., B.F.), Massachusetts General Hospital, Harvard Medical School, Boston.
Isabel L LangenbachDepartment of Radiology, Cardiovascular Imaging Research Center (CIRC) (J.M.B., J.K., N.M.K., I.L.L., M.J., M.C.L., M.T.L., B.F.), Massachusetts General Hospital, Harvard Medical School, Boston.
Matthias JungDepartment of Radiology, Cardiovascular Imaging Research Center (CIRC) (J.M.B., J.K., N.M.K., I.L.L., M.J., M.C.L., M.T.L., B.F.), Massachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0002-1124-4284
Michelle D KelseyDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.D.K., N.P., S.H.S., P.S.D.).ORCID 0000-0002-2169-043X
Marcel C LangenbachDepartment of Radiology, Cardiovascular Imaging Research Center (CIRC) (J.M.B., J.K., N.M.K., I.L.L., M.J., M.C.L., M.T.L., B.F.), Massachusetts General Hospital, Harvard Medical School, Boston.
Neha PagidipatiDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.D.K., N.P., S.H.S., P.S.D.).ORCID 0000-0002-5004-8868
Svati H ShahDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.D.K., N.P., S.H.S., P.S.D.).ORCID 0000-0002-3495-2830
Michael T LuDepartment of Radiology, Cardiovascular Imaging Research Center (CIRC) (J.M.B., J.K., N.M.K., I.L.L., M.J., M.C.L., M.T.L., B.F.), Massachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0003-4696-9610
Maros FerencikKnight Cardiovascular Institute, Oregon Health & Science University (M.F.).ORCID 0000-0001-5872-2223
Pamela S DouglasDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.D.K., N.P., S.H.S., P.S.D.).ORCID 0000-0001-9876-4049
Borek FoldynaDepartment of Radiology, Cardiovascular Imaging Research Center (CIRC) (J.M.B., J.K., N.M.K., I.L.L., M.J., M.C.L., M.T.L., B.F.), Massachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0002-2466-4827
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
PROMISE Trial: Clinical Coordinating CenterR01HL098237 · NHLBI · DUKE UNIVERSITY · PI DOUGLAS, PAMELA SUSAN · 2009 to 2014
$27.3M
PROMISE Trial: SDCCR01HL098236 · NHLBI · DUKE UNIVERSITY · PI LEE, KERRY L · 2009 to 2014
$5.0M
Clinical and Molecular Epidemiology of High Risk Coronary PlaqueR01HL146145 · NHLBI · DUKE UNIVERSITY · PI DOUGLAS, PAMELA SUSAN, FOLDYNA, BOREK · 2019 to 2022
$4.8M
PROMISE Trial: Dx CoreR01HL098305 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HOFFMANN, UDO · 2009 to 2014
$3.5M
Pericoronary adipose tissue density a novel CT-derived marker of local inflammation and coronary artery disease in people living with HIVR01HL170877 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Borek Foldyna · 2023 to 2026
backgroundQuantitative coronary plaque measures differ in prognostic value between women and men. It remains unclear whether cardiovascular risk increases proportionally with plaque extent in both sexes. We aimed to compare cardiovascular risk trajectories across quantitative coronary plaque measures in women and men with stable chest pain.
methodsWe analyzed data from the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) coronary computed tomography angiography arm, quantifying total coronary plaque volume and burden (plaque burden [PB]; % vessel volume), including calcified, noncalcified, and low-attenuation components. Associations with major adverse cardiovascular events (death, myocardial infarction, or unstable angina hospitalization) were assessed using sex-stratified spline Cox models over a median 26 months (interquartile range, 18-34).
resultsAmong 4267 patients (mean age, 60.4±8.2; 2199 women), plaque was less frequent in women (55% versus 75%;
conclusionsIn women, major adverse cardiovascular events appeared to emerge at a lower PB, and to rise more sharply. Findings support sex-specific interpretation of coronary computed tomography angiography-derived plaque metrics for timely intervention in women. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01174550.
Indexed as
Computed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsPlaque, AtheroscleroticAgedFemaleHeart Disease Risk FactorsHumansIncidenceMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk Assessmentcardiovascular diseaseschest paincomputed tomography angiographycoronary artery diseasemyocardial infarctionwomen’s health
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Risk in Women Emerges at Lower Coronary Plaque Burden Than in Men: PROMISE Trial. · full record | Socratic