ArticleFrontiers in neurology
Impact of gender differences on prognosis in patients with acute cerebral infarction associated with REM-related obstructive sleep apnea: a retrospective cohort study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Serum hypocretin, neurofilament heavy chain, and interleukin-1β as combined predictors of sleep disorders following acute ischemic stroke.Frontiers in neuroscience · 2026Article
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8 authors.
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Abstract
Background: Acute cerebral infarction (ACI) comorbid with rapid eye movement-related obstructive sleep apnea (REM-OSA) worsens prognosis, but gender-specific differences in outcomes and their underlying mechanisms remain understudied, and this gap limits the development of personalized interventions for female patients. Objective: To analyze gender differences in prognosis among ACI patients with REM-OSA and identify contributing factors, providing evidence for improving outcomes. Methods: A retrospective analysis of acute cerebral infarction (ACI) patients with REM-related obstructive sleep apnea (REM-OSA) admitted to the Department of Neurology, Affiliated Hospital of Yangzhou University, from February 2023 to February 2025. The study included 140 patients (71 females, 69 males) with ACI and REM-OSA, who underwent all-night polysomnographic monitoring. The data collected included: (1) baseline clinical characteristics; (2) laboratory indicators; (3) subjective sleep assessments, including sleep quality, daytime sleepiness, and emotional state; (4) objective sleep monitoring data (video polysomnography during the night); (5) prognostic indicators, including the Modified Rankin Scale (mRS) and the National Institutes of Health Stroke Scale (NIHSS). Results: Female patients had significantly higher discharge NIHSS scores ( Conclusion: Female ACI patients with REM-OSA have poorer prognosis, likely linked to severe REM hypoxia and inflammation. Gender-specific REM-OSA screening and interventions are warranted.
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