SynthesisFrontiers in neurology2026
Association between the systemic immune-inflammation index and prognosis in patients with stroke: a meta-analysis of cohort studies.
Synthesis in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis.Frontiers in psychiatry · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The systemic immune-inflammation index (SII) is a newly recognized biomarker of inflammation. Although several studies have suggested that SII may aid in diagnosis of stroke and in predicting treatment outcomes, the findings remain inconsistent, and its relationship with clinical prognosis is still unclear. Therefore, we conducted a comprehensive systematic review and meta-analysis to explore the relationship between SII and clinical outcomes in patients with stroke. Methods: We systematically searched four databases (PubMed, Embase, Cochrane Library, and Web of Science). The study adhered strictly to PRISMA guidelines. We assessed the risk of bias across the included studies using the Newcastle-Ottawa Scale. Key outcome indicators included poor functional outcome (modified Rankin Scale, mRS ≥ 2), mortality, stroke severity (National Institutes of Health Stroke Scale, NIHSS >4), and intracranial hemorrhage. Results: A total of 11 cohort studies comprising 24,922 patients with stroke were included. Our results demonstrated that elevated SII was strongly linked to increased mortality (OR = 1.58, 95% CI: 1.23-2.02; Conclusion: SII appears to have potential value in predicting stroke prognosis and may help clinicians assess outcomes by calculating patients' SII levels. Nevertheless, given the limitations of the available evidence, further research is needed to clarify its practical clinical utility. Larger samples and multicenter clinical trials are required to obtain more robust conclusion. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251163979, identifier PROSPERO (CRD420251163979).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.