ArticleFrontiers in microbiology2026
Myeloid-derived suppressor cells and their subsets serve as potential biomarkers for the progression of brucellosis.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Brucellosis remains the most prevalent zoonotic disease globally and can cause chronic persistent infection, which in turn results in prolonged recovery challenges. Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with strong immunosuppressive activity. Toll-like receptor 4 (TLR4) can initiate the body's inflammatory response, leading to an inflammatory cytokine storm. Programmed death ligand 1 (PD-L1) modulates the strength and duration of the immune response, diminishing the immune system's ability to eliminate pathogens and subsequently affecting disease progression and prognosis. However, the clinical significance of TLR4 Methods: A total of 88 patients with acute brucellosis infection (ABI), 66 patients with chronic brucellosis infection (CBI), and 82 healthy controls (HC) subjects were enrolled. Flow cytometry was used to detect TLR4 Results: Our study found that the frequency of MDSC in CBI group was significantly elevated. The levels of Arg1 and iNOS were also positively correlated with the levels of TLR4 Conclusion: These findings expand the current understanding of persistent Brucella infection, and highlight that TLR4
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