ReviewFrontiers in neuroscience2026
Recent advances in postoperative delirium in elderly patients: pathophysiological mechanisms, risk prediction, and therapeutic strategies.
Review in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between the geriatric nutritional risk index and postoperative delirium: a meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Association between frailty and postoperative delirium after transcatheter aortic valve replacement: a meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Effects of remimazolam and sevoflurane on postoperative delirium and early cognitive impairment in elderly patients after laparoscopic-assisted gastrointestinal surgery: a randomized clinical trial.Frontiers in medicine · 2026Trial
- The Impact of Humanistic Postoperative Care Integrated With the 6S Management Model on Postoperative Delirium and Psychiatric Symptoms in Patients With Schizophrenia Undergoing Surgery.Actas espanolas de psiquiatria · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative delirium (POD) is a common acute neuropsychiatric syndrome occurring during the perioperative period, characterized by disturbances in consciousness, attention, and cognition. It frequently develops in elderly patients as a consequence of surgery-induced neurofunctional impairment and physiological stress. Clinically, POD manifests with an abrupt onset, fluctuating course, and symptoms such as confusion and disorganized thinking. Multiple predisposing and precipitating factors contribute to its occurrence, including preoperative mental status, general physical condition, diabetes mellitus, electrolyte imbalances, type and duration of surgery, intraoperative blood loss, anesthesia management, and medication use. Understanding the underlying mechanisms of POD in older adults and implementing targeted preventive and therapeutic interventions are crucial for reducing its incidence, enhancing perioperative recovery, and improving the overall safety of surgical care in the elderly population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.