Evidence map›Paper›PMID 41725950›Full record

ReviewFrontiers in bioengineering and biotechnology2026

pH-responsive nanozymes: multifunctional platforms for biomedical catalysis toward clinical translation.

Xiaofei Zhuang, Shanshan Gao, Yueqin Tao, Mujie Yuan, Zhiwu Han, Ying Wang

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaofei ZhuangDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Shanshan GaoDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yueqin TaoDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Mujie YuanDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Zhiwu HanDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Ying WangDepartment of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an emerging class of smart nanomaterials, pH-responsive nanozymes are capable of realizing dynamic regulation of catalytic activity according to microenvironmental acidity and alkalinity. The material system encompasses noble metals, metal oxides, metal sulfides, carbon-based nanozymes, and metal-organic frameworks. Through engineering strategies such as surface ligand modification, heterogeneous atom doping and core-shell structure design, these nanozymes can achieve precise response to complex biological microenvironments, and show unique catalytic properties in the lesion site with specific pH. In recent years, pH-responsive nanozymes have been applied in various biomedical fields, such as tumor therapy, antimicrobial, wound healing, and anti-inflammation, to enhance therapeutic efficacy through controlled activation and targeted drug delivery. However, they still face many challenges in clinical translation, such as

Indexed as

applicationsbiomedicalclinical translationenzyme mimicsnanozymespH-responsive

Identifiers

PMID41725950
PMCPMC12920518

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.