Evidence map›Paper›PMID 41726046›Full record

ArticleJournal of the Society for Cardiovascular Angiography & Interventions2026

Right-Sided Extravalvular Damage: An Overlooked Driver of Risk Model Failure in Low-Flow, Low-Gradient Aortic Stenosis.

Yash Prakash, Akarsh Sharma, Lakshay Chopra, Mihir Prakash, Eileen Galvani, Oludamilola Akinmolayemi, Carlo Mannina, Ranbir Singh, Jonathan L Halperin, Samin K Sharma and 3 more

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In one paragraph

Article in Journal of the Society for Cardiovascular Angiography & Interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yash PrakashSamuel Bronfman Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Akarsh SharmaSamuel Bronfman Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Lakshay ChopraDepartment of Cardiology, Mount Sinai Morningside and Mount Sinai West, New York, New York.
Mihir PrakashCollege of Arts and Sciences, Case Western Reserve University, Cleveland, Ohio.
Eileen GalvaniSamuel Bronfman Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Oludamilola AkinmolayemiMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York.
Carlo ManninaDepartment of Cardiology, Mount Sinai Morningside and Mount Sinai West, New York, New York.
Ranbir SinghDepartment of Cardiology, Mount Sinai Morningside and Mount Sinai West, New York, New York.
Jonathan L HalperinMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York.
Samin K SharmaMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York.
Annapoorna S KiniMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York.
Deepak L BhattMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York.
Stamatios LerakisMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, New York.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) score is guideline-endorsed for estimating procedural risk in aortic stenosis (AS) but tends to overestimate long-term mortality after transcatheter aortic valve replacement (TAVR). This study aimed to evaluate whether markers of right-sided extravalvular damage improve STS-PROM's performance in predicting 1-year mortality post-TAVR for patients with low-flow, low-gradient AS. Methods: Four hundred ten patients with valve area ≤1.0 cm Results: Right-sided extravalvular damage was independently associated with increased 1-year mortality (OR, 2.45; 95% CI, 1.34-4.46; Conclusions: Markers of right-sided extravalvular damage conferred meaningful prognostic value in low-flow, low-gradient AS by correcting the STS-PROM score's tendency to overestimate post-TAVR mortality. The added value of these markers was most pronounced in moderate-risk patients, for whom existing tools appear least reliable. These markers may improve patient selection for TAVR and merit evaluation in other severe AS phenotypes.

Indexed as

low-flow low-gradient aortic stenosispatient selectionright-sided extravalvular damagerisk predictiontranscatheter aortic valve replacement

Identifiers

PMID41726046
PMCPMC12923347

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.