Evidence map›Paper›PMID 41726239›Full record

ArticleRSC advances2026

Mechanistic profiling and optimized production of Altenusin, a fungal carboxy-biphenyl scaffold for tyrosinase inhibition.

Nicolas Reyes Castillo, Marius Spohn, Celine M Zumkeller, Michael Marner, Yang Liu, Maria A Patras, Christian Kersten, Francesca Magari, Arnold Grünweller, Till F Schäberle

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicolas Reyes CastilloNatural Product Research, Institute for Insect Biotechnology, Justus-Liebig-University Giessen 35392 Gießen Germany till.f.schaeberle@agrar.uni-giessen.de.ORCID https://orcid.org/0000-0003-2751-213X
Marius SpohnNatural Product Research, Institute for Insect Biotechnology, Justus-Liebig-University Giessen 35392 Gießen Germany till.f.schaeberle@agrar.uni-giessen.de.ORCID https://orcid.org/0000-0002-1772-3614
Celine M ZumkellerNatural Product Research, Institute for Insect Biotechnology, Justus-Liebig-University Giessen 35392 Gießen Germany till.f.schaeberle@agrar.uni-giessen.de.ORCID https://orcid.org/0000-0002-7906-575X
Michael MarnerNatural Product Research, Institute for Insect Biotechnology, Justus-Liebig-University Giessen 35392 Gießen Germany till.f.schaeberle@agrar.uni-giessen.de.ORCID https://orcid.org/0000-0002-1024-1567
Yang LiuNatural Product Research, Institute for Insect Biotechnology, Justus-Liebig-University Giessen 35392 Gießen Germany till.f.schaeberle@agrar.uni-giessen.de.
Maria A PatrasNatural Product Research, Institute for Insect Biotechnology, Justus-Liebig-University Giessen 35392 Gießen Germany till.f.schaeberle@agrar.uni-giessen.de.
Christian KerstenInstitute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz Staudinger Weg 5 55128 Mainz Germany.ORCID https://orcid.org/0000-0001-9976-7639
Francesca MagariInstitute of Pharmaceutical Chemistry, Philipps-University Marburg Marbacher Weg 6 35032 Marburg Germany.
Arnold GrünwellerInstitute of Pharmaceutical Chemistry, Philipps-University Marburg Marbacher Weg 6 35032 Marburg Germany.
Till F SchäberleNatural Product Research, Institute for Insect Biotechnology, Justus-Liebig-University Giessen 35392 Gießen Germany till.f.schaeberle@agrar.uni-giessen.de.ORCID https://orcid.org/0000-0001-9947-8079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tyrosinase is a binuclear copper oxidase central to melanogenesis and food browning and is a major target for depigmenting and anti-browning agents. Here we evaluate Altenusin, a fungal carboxy-biphenyl polyketide, as a tyrosinase-inhibitor scaffold by combining structure-based screening, enhanced fermentation and mechanistic enzymology. Docking against the mushroom tyrosinase

Identifiers

PMID41726239
PMCPMC12917734

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.