ArticleMatter2026
Ultrafast-relaxing and photopolymerizable PEG hydrogels enable viscoelasticity-mediated cell remodeling in synthetic matrices.
Article in Matter, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cell-Type-Tailored Hydrogels for Adoptive Cell Therapy in Cancer.Gels (Basel, Switzerland) · 2026Review
- Microscale Mechanical Cues in Hydrogels: Engineering Strategies to Modulate Cell Fates in Three Dimensions.Cell biomaterials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
Synthetic hydrogels provide powerful material platforms to engineer cellular microenvironments with control over stiffness, viscoelasticity, porosity, degradability, and biochemical signals. Here, we demonstrate how orthogonal crosslinking reactions allow fabrication of covalent adaptable networks to tailor photopolymerizable bioresin formulations relevant for tissue engineering. Specifically, we synthesize multifunctional poly(ethylene glycol) (PEG) macromers containing dynamic boronate ester bonds and dithiolane and norbornene moieties that allow for photopolymerization and projection-based biofabrication. These materials are used to print human mesenchymal stromal cells (MSCs) in formulations where the ratio of elastic versus adaptable crosslinks is engineered to study and manipulate MSC spreading, actin structure, and macroscopic material-level deformation. We demonstrate how material and print parameters, peptide ligands, actomyosin-modulating drug treatments, and cell types influence cell-material interactions and emergence of morphogenesis that is uniquely enabled by viscoelasticity. The presented materials introduce a versatile strategy for spatiotemporal control over dynamic mechanical properties in cell-laden matrices.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.