Penalized Regression Based Proteome-Wide Association Study Reveals Potential Population-Specific Drug Targets for Alzheimer's Disease in European and African American Cohorts.

Shuo Shi, Shijun Liu, You Liu, Quanchao Lu

Abstract read

In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Shuo ShiBrandeis University, Waltham, MA, USA.

Shijun LiuCarnegie Mellon University, Pittsburgh, PA, USA.

You LiuUniversity of Michigan, Ann Arbor, MI, USA.

Quanchao LuGeorgia Institute of Technology, Atlanta, GA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder with significant genetic underpinnings, yet effective treatments remain elusive. To bridge the gap between genetic discoveries and therapeutic development, we conducted a penalized regression based proteome-wide association study (PWAS) in both European and African American populations. Using publicly available GWAS summary statistics and the BLISS model, we identified 37 protein-coding genes significantly associated with AD risk, including APOE and BCAM in both populations. We further applied the GREP model to prioritize repositionable drugs targeting these genes, identifying 30 significant disease-target-drug pairs. Notably, Ramipril and BAY 85-8501 emerged as top candidates for AD treatment in European and African American populations, respectively. These findings highlight ancestry-specific drug targets, demonstrating the importance of diverse genetic studies in AD research and providing novel avenues for therapeutic intervention.

Indexed as

Alzheimer DiseaseBlack or African AmericanGenome-Wide Association StudyProteomeWhite PeopleHumansRegression AnalysisProteome

Identifiers

PMID41726398

PMCPMC12919417

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.