Evidence map›Paper›PMID 41726540›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2024

KERAP: A Knowledge-Enhanced Reasoning Approach for Accurate Zero-shot Diagnosis Prediction Using Multi-agent LLMs.

Yuzhang Xie, Hejie Cui, Ziyang Zhang, Jiaying Lu, Kai Shu, Fadi Nahab, Xiao Hu, Carl Yang

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A comprehensive survey of AI agents in healthcare.Journal of biomedical informatics · 2026
    Review
  2. Enhanced Atrial Fibrillation Prediction in ESUS Patients with Hypergraph-based Pre-training.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuzhang XieEmory University, Atlanta, GA.
Hejie CuiStanford University, Palo Alto, CA.
Ziyang ZhangEmory University, Atlanta, GA.
Jiaying LuEmory University, Atlanta, GA.
Kai ShuEmory University, Atlanta, GA.
Fadi NahabEmory University, Atlanta, GA.
Xiao HuEmory University, Atlanta, GA.
Carl YangEmory University, Atlanta, GA.

Funding

Understanding Diabetes Heterogeneity via Mining Multimodality Interconnected DataK25DK135913 · NIDDK · EMORY UNIVERSITY · PI Ji Carl Yang · 2023 to 2026
$687k
NIDDK NIH HHS K25 DK135913
6 · The paper itself

Abstract

Medical diagnosis prediction plays a critical role in disease detection and personalized healthcare. While machine learning (ML) models have been widely adopted for this task, their reliance on supervised training limits their ability to generalize to unseen cases, particularly given the high cost of acquiring large, labeled datasets. Large language models (LLMs) have shown promise in leveraging language abilities and biomedical knowledge for diagnosis prediction. However, they often suffer from hallucinations, lack structured medical reasoning, and produce useless outputs. To address these challenges, we propose KERAP, a knowledge graph (KG)-enhanced reasoning approach that improves LLM-based diagnosis prediction through a multi-agent architecture. Our framework consists of a linkage agent for attribute mapping, a retrieval agent for structured knowledge extraction, and a prediction agent that iteratively refines diagnosis predictions. Experimental results demonstrate that KERAP enhances diagnostic reliability efficiently, offering a scalable and interpretable solution for zero-shot medical diagnosis prediction.

Indexed as

Diagnosis, Computer-AssistedLarge Language ModelsMachine LearningHumansNatural Language ProcessingPrediction AlgorithmsPredictive Learning Models

Identifiers

PMID41726540
PMCPMC12919460

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.