Evidence map›Paper›PMID 41726579›Full record

ArticlePediatric investigation2026

Therapeutic potential of tetrahydroxylated bile acids in reducing liver injury: Insights from the

Li Wang, Yue Yu, Jiayan Feng, Yanan Zhang, Renxue Wang, Huiyu She, Teng Liu, Victor Ling, Jianshe Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li WangThe Center for Pediatric Liver Diseases Children's Hospital of Fudan University, National Children's Medical Center Shanghai China.ORCID https://orcid.org/0000-0001-7683-5707
Yue YuThe Center for Pediatric Liver Diseases Children's Hospital of Fudan University, National Children's Medical Center Shanghai China.
Jiayan FengDepartment of Pathology Children's Hospital of Fudan University, National Children's Medical Center Shanghai China.
Yanan ZhangThe Center for Pediatric Liver Diseases Children's Hospital of Fudan University, National Children's Medical Center Shanghai China.
Renxue WangBC Cancer Agency Vancouver British Columbia Canada.
Huiyu SheThe Center for Pediatric Liver Diseases Children's Hospital of Fudan University, National Children's Medical Center Shanghai China.
Teng LiuThe Center for Pediatric Liver Diseases Children's Hospital of Fudan University, National Children's Medical Center Shanghai China.
Victor LingBC Cancer Agency Vancouver British Columbia Canada.
Jianshe WangThe Center for Pediatric Liver Diseases Children's Hospital of Fudan University, National Children's Medical Center Shanghai China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: The production of tetrahydroxylated bile acids (THBAs) is associated with better prognosis in some cholestatic patients as well as in multidrug resistance protein 2 knockout ( Objective: To evaluate the effects of THBA (3α,6α,7α,12α-Tetrahydroxy-10β,13β-pentanoic acid) in Methods: THBA was administered to Results: THBA administration reduced serum alanine aminotransferase ( Interpretation: THBA effectively alleviated cholestatic liver injury and fibrosis, and may represent a potential agent for the medical management of such diseases.

Indexed as

CholestasisMousePortal fibrosisTetrahydroxylated bile acidZFYVE19

Identifiers

PMID41726579
PMCPMC12921634

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.