Evidence map›Paper›PMID 41726710›Full record

ArticleACS omega2026

Killing of Gold Nanorods-Loaded Human Cardiac Fibroblasts Mediated by Photo-Thermal Activation.

Erica Floris, Flaminia Pompeo, Vittorio Picchio, Selenia Miglietta, Vincenzo De Mei, Claudia Cozzolino, Francesca Icolaro, Vincenzo Petrozza, Giacomo Frati, Francesca Petronella and 3 more

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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Erica FlorisDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.
Flaminia PompeoInstitute of Crystallography, National Research Council of Italy, CNR-IC, 00010 Montelibretti (RM), Italy.
Vittorio PicchioDepartment of Angio-Cardio-Neurology, IRCCS Neuromed, Via Atinense 18, Pozzilli, 86077 Isernia, Italy.
Selenia MigliettaDepartment of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, Via A. Borelli 50, 00161 Rome, Italy.
Vincenzo De MeiDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.
Claudia CozzolinoDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.
Francesca IcolaroDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.
Vincenzo PetrozzaDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.
Giacomo FratiDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.ORCID https://orcid.org/0000-0003-2703-3761
Francesca PetronellaInstitute of Crystallography, National Research Council of Italy, CNR-IC, 00010 Montelibretti (RM), Italy.ORCID https://orcid.org/0000-0003-1583-5564
Isotta ChimentiDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.
Francesca PaganoInstitute of Biochemistry and Cell Biology, National Research Council of Italy, Via E. Ramarini 32, 00015 Monterotondo Scalo (RM), Italy.
Luciano De SioDepartment of Medical Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.ORCID https://orcid.org/0000-0002-2183-6910

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac fibrosis is a pathological process associated with several heart diseases, characterized by extracellular matrix deposition by cardiac fibroblasts. Photothermal therapy is a minimally invasive medical treatment that uses nanomaterials to convert external light into localized heating. On these premises, we report an innovative approach that exploits gold nanorods (AuNRs)-mediated plasmonic photothermal therapy (PPTT) for selective ablation of AuNR-loaded human cardiac fibroblasts (hCFs). Cellular uptake is confirmed by treating hCFs with AuNRs, irradiating them with an 808 nm continuous-wave (CW) laser, and performing ultrastructural electron microscopy analysis. Measurements of extinction spectra, temperature variation, and cell viability were conducted. Results show that hCFs internalize AuNRs effectively without cytotoxicity, and extinction spectra reveal a concentration-dependent redshift of the longitudinal plasmon bands. Upon laser irradiation, AuNR-loaded hCFs experience a temperature increase, leading to cell death in proportion to AuNRs concentration. In coculture systems, AuNR-loaded hCFs are ablated while the viability of surrounding nonloaded cells (fibroblasts or cardiomyocytes) remains unaffected, demonstrating that hCFs can internalize AuNRs and be effectively ablated through PPTT. Our results highlight the potential of AuNRs for targeted cardiac cell ablation with minimal impact on adjacent cells.

Identifiers

PMID41726710
PMCPMC12917637

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.