Evidence map›Paper›PMID 41726946›Full record

ArticlebioRxiv : the preprint server for biology2026

Rhomboid protease Rhbdl2 regulates macrophage recruitment and wound regeneration in zebrafish.

Saroj Gourkanti, Gayathri Ramakrishnan, Yazmin Munoz, Rosa M Chavez, Jacqueline Cheung, Jan Dohnálek, Taylor J Schoen, Katie Martin, Matthew Lovett-Barron, Thomas Whisenant and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Saroj GourkantiSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9352-0096
Gayathri RamakrishnanSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0009-0003-5118-2764
Yazmin MunozSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.
Rosa M ChavezSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.
Jacqueline CheungSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.
Jan DohnálekInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, Prague, 1660 100, Czech Republic.ORCID 0000-0002-1556-2984
Taylor J SchoenSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5389-6133
Katie MartinSchool of Biological Sciences, Department of Neurobiology, University of California San Diego, La Jolla, CA 92093, USA.
Matthew Lovett-BarronSchool of Biological Sciences, Department of Neurobiology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-1425-5277
Thomas WhisenantUniversity of Chemistry and Technology, Prague, Technická 5, Prague, Czech Republic.ORCID 0000-0002-2838-1605
Kvido StrisovskyInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, Prague, 1660 100, Czech Republic.ORCID 0000-0003-3677-0907
Sonya E NealSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-9618-8428

Funding

The Discovery of Molecules and Mechanisms of the Rhomboid SuperfamilyR35GM133565 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sonya Elina Neal · 2019 to 2026
$2.9M
Functional maturation of neural circuits for biological motion perception and social engagementDP2EY036251 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Lovett-Barron · 2023 to 2026
$2.3M
NEI NIH HHS DP2 EY036251NIGMS NIH HHS R35 GM133565
6 · The paper itself

Abstract

Tissue regeneration requires tight control of immune cell behavior, yet the mechanisms that restrain immune-driven regenerative responses remain poorly defined. Here, we identify the rhomboid intramembrane serine protease Rhbdl2 as a critical regulator of regeneration in zebrafish. We generated

Indexed as

macrophageneutrophilregenerationRhbdl2rhomboid proteasewounding healing

Identifiers

PMID41726946
PMCPMC12918973

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.