Evidence map›Paper›PMID 41727022›Full record

ArticlebioRxiv : the preprint server for biology2026

A Preoptic Neurocircuit That Modulates Metabolic Flexibility.

Julian M Roessler, Matthew Alkire, Nathan Nigrin, Haorui Wang, Christopher M Reid, Marissa D Cortopassi, Millenia Waite, Brooke Linnehan, Eric C Griffith, Mollie Madigan and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Julian M RoesslerWhitehead Institute for Biomedical Research; Cambridge, MA, USA.ORCID 0000-0003-1893-5720
Matthew AlkireWhitehead Institute for Biomedical Research; Cambridge, MA, USA.
Nathan NigrinWhitehead Institute for Biomedical Research; Cambridge, MA, USA.ORCID 0009-0005-5499-2134
Haorui WangWhitehead Institute for Biomedical Research; Cambridge, MA, USA.
Christopher M ReidWhitehead Institute for Biomedical Research; Cambridge, MA, USA.ORCID 0000-0002-9101-1447
Marissa D CortopassiDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Millenia WaiteWhitehead Institute for Biomedical Research; Cambridge, MA, USA.
Brooke LinnehanWhitehead Institute for Biomedical Research; Cambridge, MA, USA.
Eric C GriffithDepartment of Neurobiology, Harvard Medical School; Boston, MA, USA.ORCID 0000-0003-0428-3215
Mollie MadiganDepartment of Comparative Medicine, Massachusetts Institute of Technology; Cambridge, MA, USA.
Tenzin KunchokWhitehead Institute for Biomedical Research; Cambridge, MA, USA.
Alexander S BanksDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1787-6925
Fabian SchulteWhitehead Institute for Biomedical Research; Cambridge, MA, USA.ORCID 0000-0001-9047-2674
Bukyung KimProgram in Molecular Medicine and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Massachusetts Chan Medical School; Worcester, MA, USA.
Bo-Yeon KimProgram in Molecular Medicine and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Massachusetts Chan Medical School; Worcester, MA, USA.
Jason K KimProgram in Molecular Medicine and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Massachusetts Chan Medical School; Worcester, MA, USA.
Siniša HrvatinWhitehead Institute for Biomedical Research; Cambridge, MA, USA.ORCID 0000-0001-7303-4218

Funding

Biology and applications of mammalian hibernation-like statesDP2DK136123 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI HRVATIN, SINISA · 2022 to 2025
$2.9M
Small Proteins and Epitranscriptomic Factors: Emerging Mechanisms in Bacterial Gene RegulationR35GM147566 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Srujana Samhita Yadavalli · 2022 to 2026
$2.0M
Cross-Disciplinary Research Training for Veterinary StudentsT35OD033655 · OD · TUFTS UNIVERSITY BOSTON · PI Cheryl A London, Kelly Ann Metcalf Pate · 2022 to 2026
$459k
NIDDK NIH HHS DP2 DK136123NIGMS NIH HHS R35 GM147566NIH HHS T35 OD033655
6 · The paper itself

Abstract

Precise, dynamic control of metabolic fuel usage in response to environmental challenges such as altered food availability or temperature change is essential for animal survival. In mammals, metabolic flexibility-the capacity to shift cellular metabolism between carbohydrate and fatty acid oxidation-is understood to be largely regulated by circulating hormones such as insulin and glucagon. However, the role of the central nervous system in coordinating fuel selection and tissue metabolic tuning remains underexplored. Here, we investigated the mechanisms that mediate metabolic reprogramming following the acute activation of torpor-associated glutamatergic Adcyap1+ torpor-regulating neurons in the anteroventral preoptic area (avPOA

Identifiers

PMID41727022
PMCPMC12918882

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.