ArticlebioRxiv : the preprint server for biology2026
Noradrenergic neuromodulation produces a NMDAR-dependent network state of respiratory rhythmogenesis in the preBötzinger Complex.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Norepinephrine (NE) is an important mediator of sympathetic activity that influences breathing. At the level of the inspiratory neural network, the preBötzinger complex (preBötC), NE modulation orchestrates changes in neuronal network dynamics that influence the stability of inspiratory rhythmogenesis. While this phenomenon has largely been attributed to NE-modulation of intrinsic excitability of inspiratory preBötC neurons, NE is also capable of modulating synaptic drive. Here, we resolve how NE affects synaptic properties and changes the activity dynamics of interconnected preBötC neurons in rhythmic brainstem slice preparations. Increased network burst amplitude and frequency coincided with enhanced inspiratory drive currents at the single neuron level. This increased drive was blocked by the NMDA receptor (NMDAR) antagonist, APV. Our
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.