Evidence map›Paper›PMID 41727116›Full record

ArticlebioRxiv : the preprint server for biology2026

Morphological innovation without gene co-option: the

Ben R Hopkins, Olga Barmina, Xinying Wang, Mandy M Situ, Haley A Bolanos, Shizhan Nie, Artyom Kopp

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ben R HopkinsDepartment of Evolution and Ecology, University of California - Davis.ORCID 0000-0002-9760-6185
Olga BarminaDepartment of Evolution and Ecology, University of California - Davis.
Xinying WangDepartment of Evolution and Ecology, University of California - Davis.
Mandy M SituDepartment of Evolution and Ecology, University of California - Davis.
Haley A BolanosDepartment of Evolution and Ecology, University of California - Davis.
Shizhan NieDepartment of Evolution and Ecology, University of California - Davis.
Artyom KoppDepartment of Evolution and Ecology, University of California - Davis.

Funding

Molecular Genetics of Evolutionary InnovationsR35GM122592 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ARTYOM KOPP · 2017 to 2026
$4.5M
Zeiss LSM 880 with Fast Mode Airyscan for the MCB LM Imaging FacilityS10OD026702 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PADDY, MICHAEL R · 2019 to 2019
$600k
NIGMS NIH HHS R35 GM122592NIH HHS S10 OD026702
6 · The paper itself

Abstract

The individualization of serially repeated homologs is one route through which novel traits are thought to evolve. Under this model, a repeated character-like a limb, digit, or sensory bristle-is individualized from its homologs by changes in the regulatory apparatus ('character identity network', ChIN) that specifies its development. Individualization then enables downstream gene networks that build the repeated character to diverge from one another in different parts of the body, ultimately allowing new phenotypic endpoints to be reached. Despite this model's intuitive appeal, the genetic mechanisms through which new ChINs rewire trait-building gene networks remain largely uncharacterized. A promising system in which to study this process is the

Identifiers

PMID41727116
PMCPMC12919057

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.