Evidence map›Paper›PMID 41727145›Full record

ArticlebioRxiv : the preprint server for biology2026

Myonuclear loss, rather than senescent myonuclei, associates with fiber type-specific atrophy in aging human skeletal muscle.

Carlos S Zepeda, Isabell Dobrzycki, Paige N Acklie, Cory M Dungan, Ronald G Jones, Kevin A Murach, Christopher W Sundberg

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carlos S ZepedaDepartment of Physical Therapy, Marquette University, Milwaukee, WI, USA.
Isabell DobrzyckiDivision of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Paige N AcklieDepartment of Physical Therapy, Marquette University, Milwaukee, WI, USA.
Cory M DunganDepartment of Health, Human Performance, and Recreation, Baylor University, Waco, TX.
Ronald G JonesDepartment of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, AK.
Kevin A MurachDepartment of Health, Human Performance, and Recreation, University of Arkansas, Fayetteville, AK.
Christopher W SundbergDepartment of Physical Therapy, Marquette University, Milwaukee, WI, USA.ORCID 0000-0002-6709-4078

Funding

Fatigability of Limb Muscle in Older Adults: Protective Effects of ExerciseR01AG048262 · NIA · MARQUETTE UNIVERSITY · PI FITTS, ROBERT H, HUNTER, SANDRA K · 2015 to 2024
$6.1M
Mediators of Muscle Rejuvenation with AgingR01AG080047 · NIA · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI Kevin Murach · 2023 to 2026
$2.3M
Mediators of Muscle Rejuvenation with AgingK02AG088465 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI Kevin Murach · 2025 to 2026
$285k
NIA NIH HHS K02 AG088465NIA NIH HHS R01 AG048262NIA NIH HHS R01 AG080047
6 · The paper itself

Abstract

Age-related reductions in whole-muscle function are attributed, in part, to pronounced atrophy of muscle fibers expressing the fast myosin heavy chain (MyHC) II isoforms. Senescence, a state of irreversible cell cycle arrest that can be characterized by DNA damage (γH2AX) and chromatin remodeling (loss of nuclear HMGB1), may contribute to skeletal muscle aging. Muscle nuclei (myonuclei) maintain fiber size and function and could exhibit senescence-associated features; however, the prevalence of senescent myonuclei and whether they contribute to fast fiber atrophy in older adults remains unknown.

Indexed as

agingcellular senescencemyonucleisarcopeniaskeletal muscle atrophy

Identifiers

PMID41727145
PMCPMC12918815

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.