Evidence map›Paper›PMID 41727267›Full record

ArticleJournal of psychiatry and brain science2025

Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders.

Brandon H Lee, Christina M Meyer, David J Speca, Elva Díaz

Abstract read
In one paragraph

Article in Journal of psychiatry and brain science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brandon H LeeDepartment of Pharmacology, School of Medicine, University of California, Davis.
Christina M MeyerDepartment of Pharmacology, School of Medicine, University of California, Davis.
David J SpecaDepartment of Pharmacology, School of Medicine, University of California, Davis.
Elva DíazDepartment of Pharmacology, School of Medicine, University of California, Davis.

Funding

UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
SynDIG1/Prrt1 regulation of extrasynaptic GluA1-containing AMPARs during plasticityR01MH119347 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DIAZ, ELVA D, HELL, JOHANNES W · 2019 to 2024
$3.3M
Learning, Memory, and Plasticity (LaMP) Training ProgramT32MH112507 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Karen Zito · 2017 to 2026
$2.4M
Investigation of the adhesion-GPCR BAI2 in excitatory synapse developmentR21NS112749 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DIAZ, ELVA D · 2019 to 2019
$432k
The Role of Brain-Specific Angiogenesis Inhibitor 2 (BAI2) in Synaptic Structural Organization and Functional DynamicsF99NS141387 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEYER, CHRISTINA · 2024 to 2025
$87k
NIGMS NIH HHS T32 GM007377NIMH NIH HHS R01 MH119347NIMH NIH HHS T32 MH112507NINDS NIH HHS F99 NS141387NINDS NIH HHS R21 NS112749
6 · The paper itself

Abstract

The adhesion G-protein coupled receptors (aGPCRs) are a family of 33 G-protein receptors consisting of ADGRA1-3, ADGRB1-3, ADGRC1-3, ADGRD1-2, ADGRE1-5, ADGRF1-5, ADGRG1-7, ADGRL1-4, and ADGRV1. Recent studies have unveiled the role of aGPCRs in numerous brain functions, including in neurodevelopment, synapse formation and maintenance, establishment of the blood-brain barrier, and myelination. Further, dysfunction of aGPCRs have been associated with disorders such as gliomas, depression, and epilepsy, among many others. Herein, we review generalized properties of aGPCRs, their brain-specific expression, associations with neurological and psychiatric diseases, and potential as future pharmacological targets.

Indexed as

BrainG-protein-coupledMental disordersNervous system diseaseNeurodevelopmentReceptorsSynapses

Identifiers

PMID41727267
PMCPMC12922695

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.