Evidence map›Paper›PMID 41727368›Full record

ArticleACS measurement science au2026

A Label-Free Nanopore Biosensor for Rapid and Highly Sensitive Detection of Actinomycin in Human Serum.

Yuan Zhao, Haiyan Zheng, Sathishkumar Munusamy, Jun Chen, Juanhua Kong, Rana Jahani, Anudha Kanaherarachchi, Shuo Zhou, Xiyun Guan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS measurement science au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuan ZhaoUniversity of Missouri, Department of Chemistry, Columbia, Missouri 65211, United States.
Haiyan ZhengUniversity of Missouri, Department of Chemistry, Columbia, Missouri 65211, United States.
Sathishkumar MunusamyUniversity of Missouri, Department of Chemistry, Columbia, Missouri 65211, United States.
Jun ChenUniversity of Missouri, Department of Chemistry, Columbia, Missouri 65211, United States.
Juanhua KongUniversity of Missouri, Department of Chemistry, Columbia, Missouri 65211, United States.
Rana JahaniUniversity of Missouri, Department of Chemistry, Columbia, Missouri 65211, United States.
Anudha KanaherarachchiUniversity of Missouri, Department of Chemistry, Columbia, Missouri 65211, United States.
Shuo ZhouUniversity of Missouri, Department of Chemistry, Columbia, Missouri 65211, United States.ORCID https://orcid.org/0000-0002-7491-3983
Xiyun GuanUniversity of Missouri, Department of Chemistry, Columbia, Missouri 65211, United States.ORCID https://orcid.org/0000-0003-2022-4872

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Actinomycin D (ActD), a potent anticancer drug, binds specifically to DNA at GpC-rich sites through intercalation and minor groove interactions. Detecting trace levels of ActD in complex biological fluids, such as human serum, is crucial for clinical, environmental, and pharmaceutical applications. Herein, we report a label-free detection method using an engineered α-hemolysin (α-HL) nanopore. In this assay, ActD binds to a ssDNA probe (GC

Indexed as

actinomycin Dbiological nanoporeDNA-drug interactionintercalationlabel-freeminor groove binding

Identifiers

PMID41727368
PMCPMC12921608

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.