Evidence map›Paper›PMID 41727405›Full record

ArticleEnvironmental science. Advances2026

Increasing PFAS concentrations in human serum correlate with elevated blood lipid levels.

Ashlee T Falls, Anna K Boatman, Jack P Ryan, Amie M Solosky, James N Dodds, Jessie R Chappel, Allison N Fry, Kaylie I Kirkwood-Donelson, Heather M Stapleton, Erin S Baker

Abstract read
In one paragraph

Article in Environmental science. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ashlee T FallsDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA erinmsb@unc.edu.ORCID https://orcid.org/0009-0001-1552-3379
Anna K BoatmanDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA erinmsb@unc.edu.ORCID https://orcid.org/0000-0003-2582-0622
Jack P RyanDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA erinmsb@unc.edu.
Amie M SoloskyDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA erinmsb@unc.edu.
James N DoddsDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA erinmsb@unc.edu.
Jessie R ChappelBioinformatics Research Center, Department of Biological Sciences, North Carolina State University Raleigh NC 27606 USA.
Allison N FryDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA erinmsb@unc.edu.
Kaylie I Kirkwood-DonelsonNational Institute of Environmental Health Sciences Durham NC 27709 USA.
Heather M StapletonNicholas School of the Environment, Duke University Durham NC 27708 USA heather.stapleton@duke.edu.ORCID https://orcid.org/0000-0002-9995-6517
Erin S BakerDepartment of Chemistry, University of North Carolina at Chapel Hill Chapel Hill NC 27514 USA erinmsb@unc.edu.ORCID https://orcid.org/0000-0001-5246-2213

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI Joel Newman Meyer · 2000 to 2026
$56.2M
Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Ivan Rusyn · 2017 to 2026
$21.2M
Understanding the role of lipids in structure and function of membrane proteinsRM1GM145416 · NIGMS · TEXAS A&M UNIVERSITY · PI Erin S Baker, Arthur D Laganowsky · 2022 to 2026
$7.4M
Mass Spectrometry-based Untargeted MetabolomicsZICES103363 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JARMUSCH, ALAN · 2021 to 2025
$6.5M
Increasing the Coverage, Sensitivity and Specificity of Rapid Lipidomic MeasurementsR01GM141277 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAKER, ERIN S · 2022 to 2025
$1.2M
Intramural NIH HHS ZIC ES103363NIEHS NIH HHS P42 ES010356NIEHS NIH HHS P42 ES027704NIGMS NIH HHS R01 GM141277NIGMS NIH HHS RM1 GM145416
6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic chemicals which have been detected in the blood of >99% people worldwide. Currently, certain PFAS are linked to elevated cholesterol levels in humans, but few studies have assessed changes in specific lipid species to assess mechanistic changes. In this study, 78 serum samples were attained from 49 participants exposed to elevated PFAS through drinking water and 29 occupationally exposed firefighters. PFAS serum concentrations were initially assessed, and drinking water exposure participants illustrated higher PFAS serum levels than both the firefighters and national median values from the National Health and Examination Survey (NHANES). Participants were then regrouped for lipidomic analyses using their summed serum concentration for 7 PFAS (Σ7 PFAS). Thirty-four participants in our study had Σ7 PFAS concentrations ≥20 ng mL

Identifiers

PMID41727405
PMCPMC12921673

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.