Evidence map›Paper›PMID 41727438›Full record

ArticleFrontiers in immunology2026

Abatacept treatment shows a modulating effect on Treg subsets in LRBA-deficient patients.

Sabine Donhauser, Emilia Salzmann-Manrique, Leon Maximilian Lueck, Julia Fekadu-Siebald, Ralf Schubert, Sabine Huenecke, Shahrzad Bakhtiar

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sabine DonhauserGoethe University Frankfurt, University Hospital, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.
Emilia Salzmann-ManriqueGoethe University Frankfurt, University Hospital, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.
Leon Maximilian LueckGoethe University Frankfurt, University Hospital, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.
Julia Fekadu-SiebaldGoethe University Frankfurt, University Hospital, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.
Ralf SchubertGoethe University Frankfurt, University Hospital, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.
Sabine HueneckeGoethe University Frankfurt, University Hospital, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.
Shahrzad BakhtiarGoethe University Frankfurt, University Hospital, Department of Pediatrics, Division for Stem Cell Transplantation and Immunology, Frankfurt am Main, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been tremendous progress in the understanding of subsets of regulatory T cells (Tregs). However, despite their theoretical importance, Treg subsets are not routinely analyzed in patients with immune dysregulation over the course of the disease and treatment. This is particularly the case in pediatric patients when the primary patient material is limited. Here, we used a rapid permeabilization assay to analyze CD4

Indexed as

AbataceptAdaptor Proteins, Signal TransducingImmunosuppressive AgentsT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsAdolescentChildChild, PreschoolFemaleHematopoietic Stem Cell TransplantationHumansInfantMaleTreatment OutcomeAbataceptAdaptor Proteins, Signal TransducingImmunosuppressive AgentsLRBA protein, humanabataceptHelios+ TregHelios- Treginborn error of immunityLRBA deficiencyregulatory T cellsTreg subpopulations

Identifiers

PMID41727438
PMCPMC12920584

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.