ReviewFrontiers in immunology2026
The evolution of antibody-secreting cell biological exploration: one mouse model at a time.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon antigenic exposure, B cells become activated and undergo differentiation into antibody-secreting cells (ASCs) which secrete thousands of antibodies per second. However, ASCs have shown themselves to be a heterogenous population which possesses capabilities well beyond just antibody secretion. Therefore, a growing need exists to more comprehensively assess ASC biology. As the rise of genetically modified mouse models has allowed for substantial gains in our understanding of immune system development and function, it also enables the exploration of ASC development and function. This Perspective article aims to highlight the evolution in mouse models which have facilitated the advancement of ASC research in areas including development, function, heterogeneity and longevity. Furthermore, we discuss the future of ASC mouse models as it pertains to their potential of furthering our understanding of ASC biology in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.