Evidence map›Paper›PMID 41727496›Full record

ArticleFrontiers in immunology2026

The TPx protein of

Xiaoqing Sun, Qianqian Mu, Biying Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. TPx Protein ofPathogens (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaoqing SunDepartment of Parasitology, Zunyi Medical University, Zunyi, China.
Qianqian MuDepartment of Parasitology, Zunyi Medical University, Zunyi, China.
Biying ZhouDepartment of Parasitology, Zunyi Medical University, Zunyi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The immunopathogenesis of cysticercosis remains elusive. This study investigates the effects of Methods: TPx protein from the excretory-secretory antigens of Results: A Treg/Th17 cell imbalance was detected in Jurkat cells following exposure to TPx, characterized by a Treg-mediated predominant immunosuppressive response. Gene Set Enrichment Analysis identified significant enrichment of the TGF-β signaling pathway and Th17 cell differentiation pathway in TPx-treated cells. TPx significantly upregulated TGF-β1, TGF-βR2, and p-Smad3 expression in cells ( Discussion: The TGF-β/Smad signaling pathway is a crucial molecular mechanism involved in the imbalance of Treg/Th17 cells induced by the TPx protein of

Indexed as

Cell DifferentiationHelminth ProteinsPeroxiredoxinsSignal TransductionSmad ProteinsTaenia soliumTh17 CellsT-Lymphocytes, RegulatoryTransforming Growth Factor betaAnimalsHumansJurkat CellsHelminth ProteinsPeroxiredoxinsSmad ProteinsTransforming Growth Factor betaTaenia solium metacestodeTGF-β signaling pathwayTh17 cellsthioredoxin peroxidaseTreg cellsTreg/Th17 cell balance

Identifiers

PMID41727496
PMCPMC12920504

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.