Evidence map›Paper›PMID 41727582›Full record

ArticleResearch square2026

Type 2 immune history imprints local training in nerve and airway associated interstitial macrophages (NAMs) for disease tolerance during lethal respiratory viral infection.

Payal Damani-Yokota, Yavor Yordanov, Eduardo D Bernier, Chaitra Sreenivasaiah, Alireza Khodadadi-Jamayran, Matthias Kugler, Stephen T Yeung, Stacey Bartlett, Valeria Mezzano, Eric Bartnicki and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Payal Damani-YokotaDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0001-5168-2329
Yavor YordanovApplied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA., United States.
Eduardo D BernierDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Chaitra SreenivasaiahApplied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA., United States.
Alireza Khodadadi-JamayranApplied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA., United States.
Matthias KuglerDivision of Pulmonary and Critical Care Medicine, New York University, New York, NY, USA.
Stephen T YeungDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Stacey BartlettDepartment of Medicine/Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, NY, 10016, USA.
Valeria MezzanoDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, USA.
Eric BartnickiDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.
Mingjun LiuDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, USA.
Fei ChenCenter for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
William C GauseCenter for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
Aristotelis TsirigosApplied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA., United States.
Iannis AifantisPerlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Mila OrtigozaDepartment of Medicine/Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, NY, 10016, USA.
Bettina NadorpCenter for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.ORCID 0000-0003-1974-8425
Musa MhlangaApplied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA., United States.ORCID 0000-0003-1381-3409
Kamal M KhannaDepartment of Microbiology, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-9328-3817

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Novel lung resident interstitial macrophage subset with distinct localization and polarizationR01AI143861 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KHANNA, KAMAL MOHAN · 2019 to 2023
$3.3M
Role of resident macrophages in type II responses and trained immunityR01AI188824 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Kamal Mohan Khanna · 2025 to 2026
$1.7M
Biology of Influenza Virus TransmissionK08AI141759 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ORTIGOZA, MILA BRUM · 2019 to 2023
$939k
Lung resident macrophage subsets in regulating tissue immunity - Resubmission - 1F32HL154598 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DAMANI-YOKOTA, PAYAL · 2021 to 2022
$85k
NCI NIH HHS P30 CA016087NHLBI NIH HHS F32 HL154598NIAID NIH HHS K08 AI141759NIAID NIH HHS R01 AI143861NIAID NIH HHS R01 AI188824
6 · The paper itself

Abstract

Severe respiratory viral disease varies widely among individuals and often reflects immunopathology rather than inadequate pathogen control, suggesting that prior immune history can prime the lung's inflammatory-regulatory balance to promote disease tolerance. Here we show that nerve- and airway-associated macrophages (NAMs), a subset of interstitial macrophages expand following type 2 inflammation induced by

Indexed as

disease toleranceefferocytosisinnate immune memorymacrophagesNAMstissue-repairtrained immunitytype 2 immunity

Identifiers

PMID41727582
PMCPMC12919208

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.