ArticleResearch square2026
CD4+ T Cell Activation and Peripheral Immune Cell Influx into the Brain Following Wildfire Smoke Exposure is Modulated by a Saturated Fat Diet.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
18 authors.
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Abstract
Over the past 40 years, wildfires across the United States have steadily increased, in terms of acreage burned. Smoke from wildfires can exacerbate several cardiovascular and respiratory diseases, with new studies highlighting potential sustained neurological outcomes. The purpose of this study was to delineate the role of peripheral immune populations in woodsmoke-induced neuroinflammation, the timeline of this response, and the impact of diet on each of these factors. Based on previous research on other pollutants and diet introduction, we included a highly saturated fatty acid (coconut oil) to represent the effects of a diet intervention that may negatively influence the severity and time course of peripheral immune infiltration. 8-week-old female C57BL/6 mice were exposed to either a sham filtered air or a woodsmoke exposure of a 0.5 mg/m
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