Evidence map›Paper›PMID 41727634›Full record

ReviewFrontiers in oncology2026

Bidirectional interactions along the microbiota-gut-brain axis in radiation-induced brain injury: mechanisms and therapeutic insights.

Yayi Yuan, Nan Wang, Kang Ning, Xuhong Dang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yayi YuanKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center of AI Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Hubei, China.
Nan WangKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center of AI Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Hubei, China.
Kang NingKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center of AI Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Hubei, China.
Xuhong DangChina National Nuclear Corporation (CNNC) Key Laboratory for Radiation Protection Technology, Shanxi Key Laboratory for Radiation Safety and Protection, Department of Radiology and Environmental Medicine, China Institute for Radiation Protection, Taiyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation therapy is widely used for the treatment of brain tumors and metastases from extracranial malignancies; however, it may also cause damage to normal brain tissue, potentially resulting in radiation-induced brain injury (RBI). Emerging evidence highlights the microbiota-gut-brain axis (MGBA) as a critical mediator of bidirectional communication between the gut microbiota and the brain, playing an important role in central nervous system (CNS) homeostasis and pathology. This review aims to summarize current evidence regarding the potential involvement of the MGBA in the pathogenic mechanisms of RBI, with particular emphasis on bidirectional interactions along this axis. We focus on underlying mechanisms, including neuroimmune and inflammatory responses, signal transduction, DNA damage, and oxidative stress. By integrating these perspectives, this review seeks to provide a novel conceptual framework for understanding RBI and to identify potential directions for future MGBA-targeted interventions.

Indexed as

brain tumorsgut microbiotamicrobiota–gut–brain axisradiation-induced brain injuryradiation therapy

Identifiers

PMID41727634
PMCPMC12916379

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.