Evidence map›Paper›PMID 41727716›Full record

ArticleChemical science2026

Machine learning-assisted screening of small-molecule drugs for suppressing protein aggregation and ROS generation based on ECL and CV dual-mode signals amplified by DNA.

Jiaqi Shi, Wenxiu Zhu, Jingyu Yan, Cong Xiao, Huiqin Yao, Lingchen Meng, Hongyun Liu, Lanqun Mao

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiaqi ShiKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University Beijing 100875 Peoples' Republic of China liuhongyun@bnu.edu.cn lqmao@bnu.edu.cn.
Wenxiu ZhuKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University Beijing 100875 Peoples' Republic of China liuhongyun@bnu.edu.cn lqmao@bnu.edu.cn.
Jingyu YanKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University Beijing 100875 Peoples' Republic of China liuhongyun@bnu.edu.cn lqmao@bnu.edu.cn.
Cong XiaoKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University Beijing 100875 Peoples' Republic of China liuhongyun@bnu.edu.cn lqmao@bnu.edu.cn.
Huiqin YaoSchool of Public Health, Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University Yinchuan 750004 People's Republic of China.ORCID https://orcid.org/0000-0003-4742-8971
Lingchen MengSchool of Public Health, Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University Yinchuan 750004 People's Republic of China.ORCID https://orcid.org/0000-0002-5244-0046
Hongyun LiuKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University Beijing 100875 Peoples' Republic of China liuhongyun@bnu.edu.cn lqmao@bnu.edu.cn.ORCID https://orcid.org/0000-0001-6698-5138
Lanqun MaoKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University Beijing 100875 Peoples' Republic of China liuhongyun@bnu.edu.cn lqmao@bnu.edu.cn.ORCID https://orcid.org/0000-0001-8286-9321

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Screening of small-molecule drugs to suppress both protein aggregation and reactive oxygen species (ROS) generation is critical for developing therapies for neurodegenerative diseases (NDs). However, existing methods are limited to characterizing only a single pathological feature (either protein aggregation or ROS generation) in a single measurement. Herein, taking α-synuclein (α-Syn) as the template protein, we developed a dual-mode electrochemical sensing platform for concurrently monitoring protein aggregation and ROS generation characteristics. A gold electrode functionalized with α-Syn

Identifiers

PMID41727716
PMCPMC12921573

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.