ArticleFrontiers in human neuroscience2026
Thalamic GABA+ levels are negatively associated with neuropsychiatric symptoms in patients with insomnia.
Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The Impact of Short-Form Video Addiction on Sleep Quality: The Mediating Roles of Emotional, Cognitive, and Executive Components.Behavioral sciences (Basel, Switzerland) · 2026Article
- Article
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7 authors.
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Abstract
Objective: Insomnia is the most common type of sleep disorder; however, the neurobiological causes and correlates of hyperarousal in insomnia remain to be fully determined, and the levels of cerebral metabolites in patients with insomnia remain unclear. This study aimed to quantify changes in cerebral metabolite levels in patients with insomnia and to explore their relationship with fatigue, anxiety, and subjective sleepiness. Methods: Twenty unmedicated patients with insomnia disorder and 21 age- and sex-matched healthy volunteers were included. The concentrations of metabolites including Results: GABA+ levels were significantly lower in patients with insomnia than in healthy controls ( Conclusion: Our results revealed alterations in the levels of GABA+ and GPC in the thalamus of patients with insomnia. These findings provide objective neurochemical evidence for the pathophysiological mechanisms of insomnia.
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