Evidence map›Paper›PMID 41727941›Full record

ArticleActa medica Philippina2026

Translation and Validation of Myeloproliferative Neoplasm-Symptom Assessment Form (MPN-SAF)-Total Symptom Score (MPN-SAF TSS) Filipino Version.

Flordeluna Z Mesina, Joy Ann V de Castro, Marissa M Alejandria

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Article in Acta medica Philippina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Flordeluna Z MesinaSection of Clinical Hematology, Department of Medicine, University of Santo Tomas, Manila, Philippines.
Joy Ann V de CastroCorazon Locsin Montelibano Memorial Regional Hospital, Bacolod City, Philippines.
Marissa M AlejandriaDepartment of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: Myeloproliferative disorders are characterized by symptoms that can potentially impair the quality of life of our Filipino patients. The Myeloproliferative Neoplasm Symptom Assessment Form-Total Symptom Score (MPN-SAF TSS) is used to determine symptoms at baseline and during treatment. A validated Filipino version of this questionnaire would be a helpful tool in assessing the burden of symptoms of Filipino patients with MPN. Understanding the symptom burden and symptom experience of patients with MPN is needed in developing a comprehensive wholistic management plan that addresses the physical and emotional aspects of a chronic disease such as MPN. This study aimed to translate the MPN-SAF TSS to the Filipino language. Methods: Translation, validation, and reliability testing of the MPN-SAF TSS was done following the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) guidelines for linguistic translation and validation. Results: No major discrepancies were found on forward and backward translation of the MPN-SAF TSS tool. The 0-10 scoring scale (where 0 = absent/as good as it can be and 10 = worst imaginable/daily/as bad as it can be) was deemed appropriate and was retained. Content and face validity as evaluated by Filipino hematologists showed that majority of the translated questions were relevant. Some words were further improved according to their valid recommendations. Ten MPN patients voluntarily answered the updated Filipino version of the questionnaire for face validity and cognitive debriefing was done to further refine the translation according to the patient's perspective. The back translation was identical to the original versions of MPN-SAF TSS.Validity and reliability testing of the revised and translated MPN-SAF TSS among 30 patients with MPN demonstrated that the MPN-SAF TSS Filipino version was conceptually equivalent with the English version, with good internal consistency (Cronbach's alpha=0.89); excellent reliability with an intraclass correlation coefficient of 0.98 and convergent validity of r=0.77. Conclusion: The Filipino version of the MPN-SAF TSS was demonstrated to be a valid and reliable tool in evaluating the symptom burden of Filipino patients with MPN.

Indexed as

Filipinomyeloproliferative neoplasmsymptom assessment formtotal symptom scoretranslationvalidation

Identifiers

PMID41727941
PMCPMC12917228

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