Evidence map›Paper›PMID 41728072›Full record

ReviewBiomaterials research2026

Exosome Augmentation Technologies for Drug Delivery and Disease Treatment: A Review.

Jun Wu, Ruibin Li, Lu Cao, Peiqi Wang, Shiqi Jiang, Yan Chen, Haoxin Fu, Xinhao Xu, Guanyang Lin, Lanjie Lei and 1 more

Abstract readReview
In one paragraph

Review in Biomaterials research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jun WuThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Ruibin LiThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Lu CaoThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Peiqi WangThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Shiqi JiangThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Yan ChenThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Haoxin FuThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Xinhao XuThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Guanyang LinThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Lanjie LeiKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang 310015, China.
Ren-Ai XuThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nanovesicles secreted by cells to exchange materials and information. Recent studies have revealed that these modified nanovesicles can be powerful tools for the diagnosis and treatment of diseases. However, few studies have reported on the acquisition and application of these functionalized exosomes. Therefore, this study provides a systematic summary of the entire process of isolation, functionalization, modification, and application of enhanced exosomes and recent progress in this field. First, the process of exosome production and principles of disease treatment are elucidated. Thereafter, the methods of exosome isolation are summarized, with a focus on improved technology centered on aptamer technology and new technology represented by microfluidics. Next, the functional modifications of the exosomes are classified and summarized. Finally, new breakthroughs in the diagnostic and therapeutic capabilities of function-enhancing exosomes compared with those of traditional exosomes are summarized, especially in terms of how these exosomes can be used in bioimaging, photothermal therapy, and other means of achieving a quantum leap in detection and therapeutic efficacy. This paper summarizes the latest research findings on engineered exosomes, with a particular focus on emerging technologies such as microfluidics and aptamers that hold significant potential. It provides a thorough analysis of their respective advantages and limitations, aiming to offer actionable insights for the future advancement and more complex applications of exosomes.

Identifiers

PMID41728072
PMCPMC12917129

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.