Evidence map›Paper›PMID 41728330›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Blood-based proteomic signatures of spontaneous menopause: Implications for later-life brain aging and Alzheimer's disease risk.

Madeline Wood Alexander, Jennifer S Rabin, Michelle Caunca, Allesandra Iadipaolo, Louisa Cornelis, Nina Miolane, Albert Pham, Julia Borger, Valentina Diaz, Emily W Paolillo and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Madeline Wood AlexanderHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada, M4N 3M5.ORCID 0000-0003-4598-0201
Jennifer S RabinHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada, M4N 3M5.
Michelle CauncaNeurovascular Division, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA, 94158.
Allesandra IadipaoloDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, California, USA, 93106.
Louisa CornelisDepartment of Physics, University of California, Broida Hall, Santa Barbara, CA, USA, 93106.
Nina MiolaneAnn S. Bowers Women's Brain Health Initiative, University of California, California, USA, 93106.
Albert PhamEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA, 94158.
Julia BorgerEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA, 94158.
Valentina DiazEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA, 94158.
Emily W PaolilloEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA, 94158.ORCID 0000-0003-4188-6998
Joel KramerEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA, 94158.
Laura PritschetAnn S. Bowers Women's Brain Health Initiative, University of California, California, USA, 93106.
Caitlin TaylorDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, California, USA, 93106.
Matthew S PanizzonCenter for Behavior Genetics of Aging, School of Medicine, University of California, San Diego, La Jolla, CA, USA, 92093.
Ramiro Eduardo Rea ReyesWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA, 53792-2420.
Marisa N DenkingerBanner Sun Health Research Institute, Sun City, AZ, USA, 85351.
Nicholas J AshtonBanner Sun Health Research Institute, Sun City, AZ, USA, 85351.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA, 53792-2420.
Emily G JacobsDepartment of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, California, USA, 93106.
Rowan SalonerEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA, 94158.ORCID 0000-0002-1351-6183
Kaitlin B CasalettoEdward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, California, USA, 94158.

Funding

Elucidating the role of endocrine aging as a risk factor for Alzheimer's DiseaseK00AG079790 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$76k
NIA NIH HHS K00 AG079790
6 · The paper itself

Abstract

Menopause is a hallmark process in biological aging that has been associated with later life neurodegenerative risk. We leveraged proteomics data from multiple cohorts (

Identifiers

PMID41728330
PMCPMC12919155

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.