ArticleOsteoarthritis and cartilage open2026
MULTIple or ONE home strengthening exercise(s) for knee osteoarthritis: Protocol for the MULTI-ONE randomised controlled trial.
Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- FREquency of strength home exercises for knee osteoarthritis pain: Protocol for the FRESH non-inferiority randomised controlled trial.Osteoarthritis and cartilage open · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine the effectiveness of a prescribed home exercise program comprised of a single strengthening exercise compared to i) a program with multiple (five) strengthening exercises and ii) control (usual care) for reducing walking pain in people with knee osteoarthritis (OA). Design: A multi-centre superiority randomised controlled trial will be conducted, involving 144 people with chronic knee pain consistent with OA. Participants will be randomised to receive i) control (usual care); ii) a prescribed home program with one strengthening exercise or; iii) a prescribed home program with multiple (five) strengthening exercises. Participants in the exercise groups will have three consultations over 3 months with a physiotherapist for prescription, monitoring and progression of their exercise program, which will be performed independently at home. The primary outcome measure will be change in walking pain measured on a numerical rating scale. Secondary outcomes will include WOMAC pain and function subscales, quality-of-life; arthritis and exercise self-efficacy; fear of movement; global rating of change; muscle strength/power; and willingness for joint replacement. Primary time-point for re-assessment will be 3 months, with a secondary time-point of 9 months, after randomisation. Ethics and dissemination: This trial is approved by the University of Melbourne Human Research Ethics Committee (#29890). Dissemination will occur via lay summaries, infographics, conference abstracts, oral presentations and journal papers. Clinical trial registration: Australian New Zealand Clinical Trials Registry ACTRN12624001226594. Prospectively registered on 9/10/2024. Conclusions: Findings will guide clinicians in choosing how many home strengthening exercises to prescribe for people with knee OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.