ReviewCureus2026
Management of Complications After Pancreaticoduodenectomy: A Narrative Review of Pathophysiology and Treatment Strategies.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreaticoduodenectomy (PD), or the Whipple procedure, remains the cornerstone operation for malignant and select benign diseases of the pancreatic head and periampullary region. Despite advances in surgical techniques and perioperative management, PD continues to be associated with high morbidity. Common complications such as postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), and postpancreatectomy hemorrhage (PPH) significantly influence recovery, healthcare costs, and long-term outcomes. A comprehensive literature review was conducted using PubMed/MEDLINE, Embase, Scopus, and Cochrane Library databases from inception to August 2025. Relevant studies, meta-analyses, clinical trials, and consensus guidelines in English were included if they addressed the incidence, pathophysiology, risk factors, diagnosis, management, or prevention of complications following PD. Data were synthesized to summarize contemporary management approaches and emerging innovations. POPF, DGE, and PPH remain the most frequent and clinically impactful complications. Advances in interventional radiology, including percutaneous drainage and endovascular embolization, have reduced reoperation rates and mortality. Supportive care-encompassing nutritional optimization, infection control, and prokinetic therapy-forms the foundation of management. Preventive strategies such as Enhanced Recovery After Surgery (ERAS) pathways, selective somatostatin analogue use, and early drain removal have shown improved outcomes. Emerging areas include artificial intelligence (AI)-based predictive models, omics-derived biomarkers, and minimally invasive or hybrid interventions. Effective management of PD complications requires a multidisciplinary, evidence-based, and patient-centered approach. Integration of interventional, pharmacologic, and preventive strategies, combined with predictive technologies and standardized definitions, is essential to reduce morbidity and enhance survival after PD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.