ArticleCureus2026
Clinical Presentation of Agenesis of Corpus Callosum Among Children in a Single Tertiary Care Center in Riyadh, Saudi Arabia.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
One of the most prevalent brain structural disorders is agenesis of the corpus callosum (ACC). ACC happens when the primary commissural fiber tracts that link the brain hemispheres are absent entirely or partially due to a disturbance of neural cell migration during fetal growth. This research was conducted based on an analytical case-series design. Specifically, a chart review was done by using the patients' charts in King Abdullah Specialized Children's Hospital (KASCH), a tertiary governmental hospital in Riyadh, Saudi Arabia, from 2015 to 2022. A non-random, non-probability consecutive sampling technique was used for this research. Thirty-seven patients were included, comprising 16 males (43.2%) and 21 females (56.8%). The ages ranged from two to 13, with 14 patients being below five years old (37.8%), 20 patients between five years old and 10 years old (54.1%), and three patients above 10 years old (8.1%). Dysmorphic features were present in 25 patients (67.6%), developmental delay in 21 patients (56.8%), seizures in 10 patients (27%), vision impairment in 12 patients (32.4%), and hearing impairment in four patients (10.8%). Cardiac comorbidities were found in 18 patients (48.6%), gastrointestinal comorbidities in 18 patients (48.6%), respiratory comorbidities in 15 patients (40.5%), neurological comorbidities in 26 patients (70.3%), and nephrological comorbidities in 10 patients (27%). MRI was used as a diagnostic tool in 28 patients (75.7%), while nine patients (24.3%) used other diagnostic methods. All comorbidities do not have any significant association with the type of ACC. However, rarely does ACC occur in an isolated manner.
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