SynthesisFrontiers in medicine2026
Application of SGLT2 inhibitors in kidney diseases: a bibliometric analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: Kidney disease represents a significant public health burden. Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed as antihyperglycemic agents, have demonstrated substantial renoprotective effects and emerged as a focal point in kidney disease research. This study aims to conduct a bibliometric analysis to evaluate the current state, research priorities, and evolving trends in SGLT2 inhibitor studies within the context of kidney disease. Methods: Relevant literature on "SGLT2 inhibitors" and "kidney diseases" was extracted from the Web of Science Core Collection, and the PubMed database was used to search for and supplement clinical research trend analysis. Bibliometric analyses and scientific visualizations were performed using R-bibliometrix, CiteSpace, and VOSviewer software to map the global research landscape. Results: A total of 1,561 publications published between 2009 and 2025 were analyzed. The annual number of publications has increased steadily. The United States is a core contributing country in this field, with strong international collaboration networks. Key institutional contributors include the University of Toronto and the University of Groningen, while prolific authors like Heerspink HJL and Wheeler DC are key contributors in this domain. Core journals are primarily concentrated in the domains of diabetes, nephrology, cardiovascular medicine, and metabolism, with the Conclusion: SGLT2 inhibitors hold considerable promise in the management of kidney disease. Future research directions are expected to emphasize elucidating their underlying mechanisms, evaluating long-term safety, and developing personalized treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.