Evidence map›Paper›PMID 41728982›Full record

ArticlemBio2026

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism.

Amelia Y M Woo, Walter J Sandoval-Espinola, Maud Bollenbach, Alison Wong, Mariko Sakanaka-Yokoyama, Qijun Zhang, Vincent Nieto, Federico E Rey, Emily P Balskus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amelia Y M WooDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0001-8338-7578
Walter J Sandoval-EspinolaDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Maud BollenbachDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Alison WongDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Mariko Sakanaka-YokoyamaDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-5517-2545
Qijun ZhangDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Vincent NietoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Federico E ReyDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-0239-7780
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0001-5985-5714

Funding

Pathogenesis of Dyslipidemia and Atherosclerosis in the Diabetic StateR01HL109650 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI BIDDINGER, SUDHA B · 2011 to 2024
$7.2M
Alan T. Waterman Award, National Science Foundation CHE-20380529Gates Foundation INV-009276National Science Foundation MCB-1650086NIH HHS R01HL109650
6 · The paper itself

Abstract

Anaerobic metabolism of dietary choline to trimethylamine (TMA) by the human gut microbiome is a disease-associated pathway. The host's impaired ability to oxidize TMA to trimethylamine-

Indexed as

CholineGastrointestinal MicrobiomeHigh-Throughput Screening AssaysAnimalsHumansMethylaminesMicePhenotypeCholineMethylaminestrimethylaminetrimethyloxamineanaerobic choline metabolismgnotobioticgut microbiomephenotypic screeningsmall molecule inhibitorsTMATMAO

Identifiers

PMID41728982
PMCPMC12977544

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.