Evidence map›Paper›PMID 41729077›Full record

ReviewJCI insight2026

New approaches to uncover COPD pathobiology and develop therapies.

Yohannes Tesfaigzi, Ali Önder Yildirim, Francesca Polverino, Thomas M Conlon, Venkataramana Sidhaye, Maor Sauler, S Vamsee Raju, Renata Z Jurkowska, Divay Chandra, Michael H Cho and 21 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JCI insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Yohannes TesfaigziDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.
Ali Önder YildirimInstitute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.
Francesca PolverinoPulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas, USA.
Thomas M ConlonInstitute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.
Venkataramana SidhayeDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Maor SaulerDivision of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
S Vamsee RajuDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Renata Z JurkowskaDivision of Biomedicine, School of Biosciences, Cardiff University, Cardiff, United Kingdom.
Divay ChandraDivision of Pulmonary, Allergy, Sleep and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Michael H ChoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ramon C SunDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Peter CastaldiChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Purushothama Rao TataDepartments of Cell Biology and Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
Kambez H BenamDepartment of Medicine, Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Linto AntonyDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mareike LehmannInstitute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.
Beata KosmiderDepartment of Microbiology, Immunology and Inflammation, Center for Inflammation and Lung Research, Temple University, Philadelphia, Pennsylvania, USA.
Karim BahmedDepartment of Microbiology, Immunology and Inflammation, Center for Inflammation and Lung Research, Temple University, Philadelphia, Pennsylvania, USA.
Zerihun H NegasiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.
Kamakshi BankotiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.
Carter SwabyKoc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.
Dave A LagowalaDepartment of Environmental Health and Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yeşim VuralKoc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.
Hasan BayramKoc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.
Rosa FanerBiomedicine Department, University of Barcelona, IDIBAPS, CIBER, Barcelona, Spain.
George WashkoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.
Dinh Son BuiCenter for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia.
Bartolome CelliDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.
Roxana Maria WasnickInstitute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.
Enid NeptuneDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

Molecular control of a novel transitional cell state in alveolar regenerationR01HL153375 · NHLBI · DUKE UNIVERSITY · PI Purushothama Rao Tata · 2020 to 2026
$3.4M
Protective effects of metformin against cigarette smoke-induced lung pathologies via regulation of fatty acids metabolismR01HL171622 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Francesca Polverino · 2024 to 2026
$2.2M
Cellular crosstalk and molecular mechanisms in the initiation and progression of pulmonary fibrosisR01HL160939 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2022 to 2025
$2.1M
Mechanisms of submucosal gland cell mediated airway regenerationR01HL146557 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2019 to 2023
$2.0M
NHLBI NIH HHS R01 HL146557NHLBI NIH HHS R01 HL153375NHLBI NIH HHS R01 HL160939NHLBI NIH HHS R01 HL171622
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) was the third leading cause of global mortality in 2011 but receives limited attention and research funding. This Review describes the current knowledge on COPD risk factors, including genetic and epigenetic determinants and their interactions with the microbiome and environmental exposures. Preclinical models are being refined and single-cell transcriptomic, metabolomic, and proteomic technologies are being implemented to investigate the molecular mechanisms of disease progression. Patient cohorts to define biomarkers of early disease and the latest approaches to diagnose pre-COPD are essential to accelerate the development of novel and effective therapeutic interventions and translate new findings into clinical trials. This Review is a summary of topics covered by a symposium organized by the COPD-iNET consortium, an international network of researchers who have established a platform that facilitates collaboration of this multidisciplinary group of preclinical, translational, and clinical researchers.

Indexed as

Pulmonary Disease, Chronic ObstructiveAnimalsBiomarkersDisease ProgressionEpigenesis, GeneticHumansMetabolomicsMicrobiotaProteomicsRisk FactorsBiomarkers

Identifiers

PMID41729077
PMCPMC12956016

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.