ArticleThe international journal of cardiovascular imaging2026
Systemic inflammation affects the association between pericoronary fat attenuation index and adverse cardiovascular risk in patients with coronary artery disease.
Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05050877 (Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention - Cardiorenal ImprovemeNt Registry II), which is not on this map. Not yet cited in PubMed.
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Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention - Cardiorenal ImprovemeNt Registry II
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Authors and funding
12 authors.
Funding
Abstract
purposeInflammation is associated with the prognosis of patients with coronary artery disease (CAD). However, the joint association of systemic inflammation and the local inflammation index of the coronary artery in adverse prognosis remains unclear.
methodsThis study included patients who underwent coronary computed tomographic angiography (CCTA) and were diagnosed with CAD. The pericoronary fat attenuation index (pFAI) represents local inflammation in the coronary arteries and is measured from CCTA images. The primary outcome was major adverse cardiovascular and cerebrovascular event (MACCE). Cox proportional hazards models were used to evaluate the association between systemic inflammation response index (SIRI), pFAI and MACCE, with interaction effects estimated.
results560 participants with CAD (mean age: 67.7 ± 10.7 years; 29.1% female) were enrolled. After a median follow-up of 5.5 years, a total of 90 (16.1%) MACCEs occurred. After fully adjusted, a high level of RCA-pFAI was associated with a higher risk of MACCE (adjusted Hazard Ratio [aHR]: 2.16, 95% confidence intervals [CI]: 1.30-3.58, P = 0.003). Interaction between SIRI and RCA-pFAI was significant (P
conclusionRCA-pFAI was a risk factor for poor prognosis of CAD patients and had a higher risk stratification value for adverse prognosis when combined with SIRI. Individuals with a high systemic and coronary artery local inflammation state may require more aggressive risk monitoring and intervention.
trial registrationThe Cardiorenal ImprovemeNt II registry (NCT05050877, 10/09/2021).
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