Evidence map›Paper›PMID 41730231›Full record

ArticleHepatology communications2026

Defining the Society of Pediatric Liver Transplantation (SPLIT) research agenda: A Delphi consensus project.

Sharad I Wadhwani, Pooja Reddy Spector, Amy G Feldman, Katryn N Furuya, Kayla Hartjes, Chaowapong Jarasvaraparn, Beau Kelly, Stacee M Lerret, Krupa Mysore, Arti Pawaria and 7 more

Abstract read
In one paragraph

Article in Hepatology communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Material economic hardships are associated with second-year hospitalizations after pediatric liver transplantation: Results from the SOCIAL-Tx study.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sharad I WadhwaniDepartment of Pediatrics, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-5565-6670
Pooja Reddy SpectorDepartment of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.ORCID 0000-0002-7002-0504
Amy G FeldmanSection of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado and Children's Hospital Colorado, Aurora, Colorado, USA.ORCID 0000-0003-4021-5615
Katryn N FuruyaDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Kayla HartjesDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Mass General Brigham for Children, Boston, Massachusetts, USA.ORCID 0000-0003-0780-1954
Chaowapong JarasvaraparnDivision of Gastroenterology and Hepatology, Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0001-8076-9378
Beau KellyDCI Donor Services, Sacramento, California, USA.ORCID 0000-0001-8682-2475
Stacee M LerretDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Milwaukee, Wisconsin, USA.
Krupa MysoreDivision of Gastroenterology and Hepatology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-9890-5518
Arti PawariaDepartment of Hepatology, Sir H. N. Reliance Foundation Hospital and Research Centre, Mumbai, Maharashtra, India.
Philip RosenthalDepartment of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
Amy ShuiDepartment of Pediatrics, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-8243-6910
Voytek SlowikDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Mercy, Kansas City, Missouri, USA.
Sarah TaylorSection of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado and Children's Hospital Colorado, Aurora, Colorado, USA.ORCID 0000-0002-3575-8386
Jennifer VittorioDepartment of Pediatrics, New York University (NYU) Transplant Institute, NYU Langone Health, New York, NY.
Pamela L ValentinoDivision of Gastroenterology and Hepatology, Department of Pediatrics, University of Washington, Seattle Children's Hospital, Seattle, Washington, USA.ORCID 0000-0002-8227-2004
Society of Pediatric Liver Transplantation (SPLIT)

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Addressing social adversity to improve outcomes among children undergoing liver transplant: the role for a health advocate on the transplant teamK23DK132454 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WADHWANI, SHARAD · 2022 to 2025
$860k
NIDDK NIH HHS K23 DK132454NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

backgroundDespite major advances in surgical and medical management, only one-third of pediatric liver transplant (LT) recipients remain morbidity-free at 10 years. The Society of Pediatric Liver Transplantation (SPLIT) published a research agenda over 10 years ago, and much progress has been made since then. An updated consensus-driven SPLIT research agenda could guide future research and funding priorities. We aimed to identify and prioritize key research needs across the continuum of pediatric LT care using a modified Delphi consensus approach.

methodsWe conducted a three-round modified Delphi process among SPLIT members. In round 1, participants submitted open-ended research priorities. In round 2, the Steering Committee synthesized these into 156 unique statements for rating. The third and final round included revision and rerating of 42 statements. Consensus was defined as a median importance rating ≥7 on a 9-point Likert scale.

resultsSixty-nine multidisciplinary experts participated in round 1, with <30% attrition across rounds. The panel identified 46 high-priority research topics, organized into 7 domains: (1) end-stage disease and waitlist management; (2) transplant access, allocation, and organ utilization; (3) perioperative management; (4) immunosuppression management; (5) transplant complications; (6) long-term health and transition to adulthood; and (7) special populations. Highest-ranked research priorities included (1) developing an updated LT waitlist allocation scoring tool, (2) identifying novel biomarkers to guide immunosuppression minimization/withdrawal, and (3) developing new organ preservation strategies to increase the availability of high-quality organs for pediatric LT candidates.

conclusionsSPLIT members identified 46 consensus research priorities that define the next frontier of pediatric LT research and provide a roadmap for investigators, funders, and health systems to improve survival and lifelong health in children after LT.

Indexed as

Biomedical ResearchLiver TransplantationPediatricsChildConsensusDelphi TechniqueEnd Stage Liver DiseaseHumansSocieties, MedicalWaiting Listsconsensuspediatric hepatologypediatric liver transplantationsociety paper

Identifiers

PMID41730231
PMCPMC12922923

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.