Evidence map›Paper›PMID 41730740›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2026

[Effect of interleukin-33 on glucocorticoid-induced osteonecrosis of the femoral head in mice].

Hongxu Li, Mengran Shen, Haoyang Liu, Yu Zhou, Fuqiang Gao, Liming Cheng, Bailiang Wang, Jinhui Ma

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongxu LiPeking University China-Japan Friendship Clinical Medical College, Beijing, 100029, P. R. China.
Mengran ShenDepartment of Orthopedics, Suqian Hospital Affiliated to Jiangsu Province Hospital, Suqian Jiangsu, 223800, P. R. China.
Haoyang LiuPeking University China-Japan Friendship Clinical Medical College, Beijing, 100029, P. R. China.
Yu ZhouPeking University China-Japan Friendship Clinical Medical College, Beijing, 100029, P. R. China.
Fuqiang GaoDepartment of Orthopedics and Joint Surgery, China-Japan Friendship Hospital, Beijing, 100029, P. R. China.
Liming ChengDepartment of Orthopedics and Joint Surgery, China-Japan Friendship Hospital, Beijing, 100029, P. R. China.
Bailiang WangPeking University China-Japan Friendship Clinical Medical College, Beijing, 100029, P. R. China.
Jinhui MaPeking University China-Japan Friendship Clinical Medical College, Beijing, 100029, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To elucidate the role of interleukin-33 (IL-33) in glucocorticoid-induced osteonecrosis of the femoral head (ONFH) in mice, with particular emphasis on its effects on bone remodeling, inflammatory regulation, and fibrosis. Methods: Results: Conclusion: IL-33 exacerbates ONFH by impairing osteoblast viability and function and inhibiting bone regeneration. Targeting the IL-33/ST2L signaling axis may represent a promising novel therapeutic strategy for ONFH.

Indexed as

Femur Head NecrosisGlucocorticoidsInterleukin-33AnimalsBone RemodelingCell DifferentiationCell ProliferationCells, CulturedCore Binding Factor Alpha 1 SubunitDisease Models, AnimalFemur HeadFibrosisInterleukin-1 Receptor-Like 1 ProteinLipopolysaccharidesMaleMethylprednisoloneCore Binding Factor Alpha 1 SubunitGlucocorticoidsIl1rl1 protein, mouseIl33 protein, mouseInterleukin-1 Receptor-Like 1 ProteinInterleukin-33LipopolysaccharidesMethylprednisoloneOsteocalcinOsteopontinRANK LigandRunx2 protein, mouseTumor Necrosis Factor-alphabone fibrosisglucocorticoid-induced osteonecrosisInterleukin-33mouseosteoblast dysfunctionosteonecrosis of the femoral head

Identifiers

PMID41730740
PMCPMC12948520

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.