Evidence mapPaperPMID 41730746Full record

ReviewZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2026

[Advances on efficacy and mechanisms of acid fibroblast growth factor for promoting injured tissue repair].

Fei Zhu, Zhounan Jiang, Xifei Qian, Yanwen Xu, Hanxiao Cheng, Jufang Zhang

Abstract readReviewEnglish Abstract
In one paragraph

Review in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fei ZhuMedical Cosmetic Center, the Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou Zhejiang, 310000, P. R. China.
Zhounan JiangMedical Cosmetic Center, the Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou Zhejiang, 310000, P. R. China.
Xifei QianMedical Cosmetic Center, the Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou Zhejiang, 310000, P. R. China.
Yanwen XuMedical Cosmetic Center, the Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou Zhejiang, 310000, P. R. China.
Hanxiao ChengMedical Cosmetic Center, the Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou Zhejiang, 310000, P. R. China.
Jufang ZhangMedical Cosmetic Center, the Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou Zhejiang, 310000, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To review the research progress on acid fibroblast growth factor (aFGF) in promoting tissue injury repair and its mechanism of action. Methods: By searching and reviewing the basic and clinical studies on aFGF published in recent years, the roles of aFGF in tissue injury including full-thickness skin, skin and mucous barrier, bone and nerve fiber were summarized. Results: As a key member of the FGF family, aFGF exhibits potent mitogenic activity, it can regulate various cells proliferation and migration, accelerate extracellular matrix synthesis, promote angiogenesis and nerve fiber repair, upregulate tight junction protein expression, and therefore exert dual regulatory effects on dermal and epidermal regeneration and repair. It demonstrates promising clinical application for full-thickness healing and skin and mucous barriers repair. Additionally, it mediates the regeneration and differentiation of osteoblasts, cardiomyocytes, and follicle cells, exhibiting potential for repairing multiple tissues and organs. Furthermore, the aFGF's functions in regulating energy metabolism, immune-inflammatory responses, and alleviating aging have revealed in recent years, indicating a broad clinical application. Conclusion: aFGF is a valuable member of the FGF family. It is widely used in various kinds of wound healing, besides, it also holds promising application in multiple tissue and organ regeneration and repair.

Indexed as

Fibroblast Growth Factor 7Fibroblast Growth FactorsWound HealingAnimalsCell DifferentiationCell ProliferationHumansNeovascularization, PhysiologicSignal TransductionSkinFibroblast Growth Factor 7Fibroblast Growth FactorsAcid fibroblast growth factormechanisms of actionsignaling pathwaytissue repair

Identifiers

PMID41730746
PMCPMC12948523

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.